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- W2897524915 abstract "Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear magnetic resonance (NMR) detectability. By synthesizing and examining over 30 NHC containing complexes, here we rationalize the key characteristics of efficient SABRE catalysis prior to using appropriate catalyst-substrate combinations to quantify the substrate's NMR detectability. These optimizations deliver polarizations of 63% for 1H nuclei in methyl 4,6-d2-nicotinate, 25% for 13C nuclei in a 13C2-diphenylpyridazine and 43% for the 15N nucleus of pyridine-15N. These high detectability levels compare favourably with the 0.0005% 1H value harnessed by a routine 1.5 T clinical MRI system. As signal strength scales with the square of the number of observations, these low cost innovations offer remarkable improvements in detectability threshold that offer routes to significantly reduce measurement time." @default.
- W2897524915 created "2018-10-26" @default.
- W2897524915 creator A5028445818 @default.
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- W2897524915 creator A5077438938 @default.
- W2897524915 creator A5086228074 @default.
- W2897524915 date "2018-10-12" @default.
- W2897524915 modified "2023-10-17" @default.
- W2897524915 title "Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design" @default.
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- W2897524915 doi "https://doi.org/10.1038/s41467-018-06766-1" @default.
- W2897524915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185983" @default.
- W2897524915 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315170" @default.
- W2897524915 hasPublicationYear "2018" @default.
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