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• W2897525845 abstract "Histamine H3 receptor (H3R), a kind of G-protein coupled receptor (GPCR), is expressed mainly in the central nervous system (CNS) and plays a vital role in homoeostatic control. This study describes the design and synthesis of a series of novel H3R antagonists based on the iso-flavone scaffold. The results of the bioactivity evaluation show that four compounds (1c, 2c, 2h, and 2o) possess significant H3R inhibitory activities. Molecular docking indicates that a salt bridge, π–π T-shape interactions, and hydrophobic interaction all contribute to the interaction between compound 2h and H3R." @default.
• W2897525845 created "2018-10-26" @default.
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• W2897525845 date "2018-01-01" @default.
• W2897525845 modified "2023-09-27" @default.
• W2897525845 title "Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H₃R antagonists" @default.
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• W2897525845 doi "https://doi.org/10.1080/14756366.2018.1509212" @default.
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