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- W2897527497 abstract "We report herein the design, synthesis, and in vitro anti‐mycobacterial activities of a series of 1,2,3‐triazole‐tetraethylene glycol tethered isatin dimers. Our results indicated that all the synthesized isatin dimers showed weak to moderate anti‐mycobacterial activities against both Mycobacterium tuberculosis H37Rv and multidrug‐resistant tuberculosis strains. Dimer 7g was found to be most active against the tested two strains with minimum inhibitory concentration of 128 and 64 μg/mL, which was eightfold more potent than INH (minimum inhibitory concentration: 512 μg/mL) against multidrug‐resistant tuberculosis. Moreover, dimer 7g (CC 50 : 62.5 μg/mL) also showed acceptable cytotoxicity against VERO cell line, could act as a lead for further investigation. The enriched structure–activity relationship may pave the way to find more effective anti‐mycobacterial candidates." @default.
- W2897527497 created "2018-10-26" @default.
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- W2897527497 date "2018-10-18" @default.
- W2897527497 modified "2023-09-25" @default.
- W2897527497 title "Design, Synthesis, and <i>In Vitro</i> Anti‐mycobacterial Activities of 1,2,3‐Triazole‐tetraethylene Glycol Tethered Isatin Dimers" @default.
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- W2897527497 doi "https://doi.org/10.1002/jhet.3349" @default.
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