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• W2897528494 startingPage "7295" @default.
• W2897528494 abstract "Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related metastatic colon cancer treated in Chile with immunotherapy (pembrolizumab). The patient exhibited a pathogenic deletion in Epithelial cell Adhesion Molecule (EPCAM) and mutS homolog 2 (MSH2) genes, and after diagnosis received 12 cycles of FOLFOX. The tumor mass, however, continued to grow, and a new metastatic mucinous adenocarcinoma of 13 mm appeared at the level of the 11th right dorsal vertebra. To treat these lesions, the patient received immunotherapy scheme with pembrolizumab (200 mg every 21 days). After only four cycles, the patient's symptoms improved and the lesions showed less metabolic activity. After 12 cycles with pembrolizumab, the patient started palliative radiation and systemic second-line treatment with FOLFIRI and Avastin. The immunotherapy scheme with pembrolizumab was capable of delaying the second-line treatment for at least 8 months, becoming a useful therapeutic option for this patient. Thus, our study highlights the importance of implementing immunotherapy treatment programs for LS-colorectal cancer patients in South American countries." @default.
• W2897528494 created "2018-10-26" @default.
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• W2897528494 date "2018-10-01" @default.
• W2897528494 modified "2023-09-25" @default.
• W2897528494 title "Evidence of response to pembrolizumab in a patient with Lynch syndrome-related metastatic colon cancer" @default.
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• W2897528494 doi "https://doi.org/10.2147/ott.s167645" @default.
• W2897528494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205820" @default.
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• W2897528494 hasPublicationYear "2018" @default.
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