Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897530293> ?p ?o ?g. }
- W2897530293 abstract "Circadian rhythms are endogenous ~24-hr oscillations usually entrained to daily environmental cycles of light/dark. Many biological processes and physiological functions including mammalian body temperature, the cell cycle, sleep/wake cycles, neurobehavioral performance, and a wide range of diseases including metabolic, cardiovascular, and psychiatric disorders are impacted by these rhythms. Circadian clocks are present within individual cells and at tissue and organismal levels as emergent properties from the interaction of cellular oscillators. Mathematical models of circadian rhythms have been proposed to provide a better understanding of and to predict aspects of this complex physiological system. These models can be used to: (a) manipulate the system in silico with specificity that cannot be easily achieved using in vivo and in vitro experimental methods and at lower cost, (b) resolve apparently contradictory empirical results, (c) generate hypotheses, (d) design new experiments, and (e) to design interventions for altering circadian rhythms. Mathematical models differ in structure, the underlying assumptions, the number of parameters and variables, and constraints on variables. Models representing circadian rhythms at different physiologic scales and in different species are reviewed to promote understanding of these models and facilitate their use. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Models of Systems Properties and Processes > Organ, Tissue, and Physiological Models." @default.
- W2897530293 created "2018-10-26" @default.
- W2897530293 creator A5031090054 @default.
- W2897530293 creator A5090162705 @default.
- W2897530293 date "2018-10-17" @default.
- W2897530293 modified "2023-10-15" @default.
- W2897530293 title "Mathematical modeling of circadian rhythms" @default.
- W2897530293 cites W1153325264 @default.
- W2897530293 cites W1497737563 @default.
- W2897530293 cites W1553776894 @default.
- W2897530293 cites W1564855882 @default.
- W2897530293 cites W1582828056 @default.
- W2897530293 cites W1599469835 @default.
- W2897530293 cites W1606385012 @default.
- W2897530293 cites W1645078148 @default.
- W2897530293 cites W1902549 @default.
- W2897530293 cites W1937375692 @default.
- W2897530293 cites W1952213740 @default.
- W2897530293 cites W1965131928 @default.
- W2897530293 cites W1968744698 @default.
- W2897530293 cites W1971327350 @default.
- W2897530293 cites W1972576332 @default.
- W2897530293 cites W1972627028 @default.
- W2897530293 cites W1973315311 @default.
- W2897530293 cites W1973592658 @default.
- W2897530293 cites W1976540475 @default.
- W2897530293 cites W1977643020 @default.
- W2897530293 cites W1979383466 @default.
- W2897530293 cites W1984409176 @default.
- W2897530293 cites W1984613079 @default.
- W2897530293 cites W1984856804 @default.
- W2897530293 cites W1989935275 @default.
- W2897530293 cites W1990536075 @default.
- W2897530293 cites W1990989220 @default.
- W2897530293 cites W1995042086 @default.
- W2897530293 cites W1997179110 @default.
- W2897530293 cites W1998019847 @default.
- W2897530293 cites W1998586959 @default.
- W2897530293 cites W2003417733 @default.
- W2897530293 cites W2004334486 @default.
- W2897530293 cites W2005246111 @default.
- W2897530293 cites W2007839079 @default.
- W2897530293 cites W2009381080 @default.
- W2897530293 cites W2012066473 @default.
- W2897530293 cites W2013537598 @default.
- W2897530293 cites W2014313900 @default.
- W2897530293 cites W2014654793 @default.
- W2897530293 cites W2014654814 @default.
- W2897530293 cites W2016752484 @default.
- W2897530293 cites W2018314770 @default.
- W2897530293 cites W2020159596 @default.
- W2897530293 cites W2020244230 @default.
- W2897530293 cites W2021771504 @default.
- W2897530293 cites W2024601773 @default.
- W2897530293 cites W2027236844 @default.
- W2897530293 cites W2029193372 @default.
- W2897530293 cites W2029276159 @default.
- W2897530293 cites W2029519468 @default.
- W2897530293 cites W2030789651 @default.
- W2897530293 cites W2032842908 @default.
- W2897530293 cites W2033733716 @default.
- W2897530293 cites W2034271648 @default.
- W2897530293 cites W2034992647 @default.
- W2897530293 cites W2035077732 @default.
- W2897530293 cites W2041845062 @default.
- W2897530293 cites W2042071929 @default.
- W2897530293 cites W2044458189 @default.
- W2897530293 cites W2047014817 @default.
- W2897530293 cites W2047279254 @default.
- W2897530293 cites W2047786938 @default.
- W2897530293 cites W2048043158 @default.
- W2897530293 cites W2050918140 @default.
- W2897530293 cites W2052778483 @default.
- W2897530293 cites W2056564149 @default.
- W2897530293 cites W2057416723 @default.
- W2897530293 cites W2057438898 @default.
- W2897530293 cites W2059367244 @default.
- W2897530293 cites W2060140960 @default.
- W2897530293 cites W2061451182 @default.
- W2897530293 cites W2064129791 @default.
- W2897530293 cites W2066229820 @default.
- W2897530293 cites W2066440682 @default.
- W2897530293 cites W2068429888 @default.
- W2897530293 cites W2068800193 @default.
- W2897530293 cites W2069742753 @default.
- W2897530293 cites W2070201373 @default.
- W2897530293 cites W2071972262 @default.
- W2897530293 cites W2073630300 @default.
- W2897530293 cites W2074539768 @default.
- W2897530293 cites W2075396624 @default.
- W2897530293 cites W2078365051 @default.
- W2897530293 cites W2079126372 @default.
- W2897530293 cites W2079442846 @default.
- W2897530293 cites W2079623891 @default.
- W2897530293 cites W2082455099 @default.
- W2897530293 cites W2083647315 @default.
- W2897530293 cites W2085237971 @default.
- W2897530293 cites W2085890242 @default.
- W2897530293 cites W2086349492 @default.
- W2897530293 cites W2088907143 @default.