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• W2897530631 endingPage "2413" @default.
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• W2897530631 abstract "Neurogenesis is sustained throughout life in the mammalian brain, supporting hippocampus-dependent learning and memory. Its permanent alteration by status epilepticus (SE) is associated with learning and cognitive impairments. The mechanisms underlying the initiation of altered neurogenesis after SE are not understood. Glial fibrillary acidic protein-positive radial glia (RG)-like cells proliferate early after SE, but their proliferation dynamics and signaling are largely unclear. We have previously reported a polarized distribution of AMPA receptors (AMPARs) on RG-like cells in vivo and postulated that these may signal their proliferation. Here, we examined the acute effects of kainate on hippocampal precursor cells in vitro and in kainate-induced SE on proliferating and quiescent clones of 5-bromo-2-deoxyuridine prelabeled hippocampal precursors in vivo. In vitro, we found that 5 μM kainate shortened the cell cycle time of RG-like cells via AMPAR activation and accelerated cell cycle re-entry of their progeny. It also shifted their fate choice expanding the population of RG-like cells and reducing the population of downstream amplifying neural progenitors. Kainate enhanced the survival of all precursor cell subtypes. Pharmacologically, kainate's proliferative and survival effects were abolished by AMPAR blockade. Functional AMPAR expression was confirmed on RG-like cells in vitro. In agreement with these observations, kainate/seizures enhanced the proliferation and expansion predominantly of constitutively cycling RG-like cell clones in vivo. Our results identify AMPARs as key potential players in initiating the proliferation of dentate RG-like cells and unravel a possible receptor target for modifying the radial glia-like cell response to SE." @default.
• W2897530631 created "2018-10-26" @default.
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• W2897530631 date "2018-10-25" @default.
• W2897530631 modified "2023-09-25" @default.
• W2897530631 title "AMPA receptors and seizures mediate hippocampal radial glia‐like stem cell proliferation" @default.
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• W2897530631 cites W1622476634 @default.
• W2897530631 cites W1646378775 @default.
• W2897530631 cites W1670625131 @default.
• W2897530631 cites W1751249310 @default.
• W2897530631 cites W1837102458 @default.
• W2897530631 cites W1882809545 @default.
• W2897530631 cites W1883162734 @default.
• W2897530631 cites W1966743979 @default.
• W2897530631 cites W1970330769 @default.
• W2897530631 cites W1981078129 @default.
• W2897530631 cites W1987375164 @default.
• W2897530631 cites W1988352722 @default.
• W2897530631 cites W1992026400 @default.
• W2897530631 cites W1997248984 @default.
• W2897530631 cites W2005994473 @default.
• W2897530631 cites W2013137971 @default.
• W2897530631 cites W2013235905 @default.
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• W2897530631 cites W2026928443 @default.
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• W2897530631 cites W2050493044 @default.
• W2897530631 cites W2059223526 @default.
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• W2897530631 cites W2080298468 @default.
• W2897530631 cites W2081322647 @default.
• W2897530631 cites W2084104345 @default.
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• W2897530631 doi "https://doi.org/10.1002/glia.23479" @default.
• W2897530631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30357924" @default.
• W2897530631 hasPublicationYear "2018" @default.
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