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- W2897530735 abstract "Abstract Previously, we have shown hyperhomocysteinemia (HHcy) to have a detrimental effect on bone remodeling, which is associated with osteoporosis. During transsulfuration, Hcy is metabolized into hydrogen sulfide (H 2 S), a gasotransmitter molecule known to regulate bone formation. Therefore, in the present study, we examined whether H 2 S ameliorates HHcy induced epigenetic and molecular alterations leading to osteoporotic bone loss. To test this mechanism, we employed cystathionine-beta-synthase heterozygote knockout mice, fed with a methionine rich diet (CBS +/− +Met), supplemented with H 2 S-donor NaHS for 8 weeks. Treatment with NaHS, normalizes plasma H 2 S, and completely prevents trabecular bone loss in CBS +/− mice. Our data showed that HHcy caused inhibition of HDAC3 activity and subsequent inflammation by imbalancing redox homeostasis. The mechanistic study revealed that inflammatory cytokines (IL-6, TNF-α) are transcriptionally activated by an acetylated lysine residue in histone (H3K27ac) of chromatin by binding to its promoter and subsequently regulating gene expression. A blockade of HDAC3 inhibition in CBS +/− mice by HDAC activator ITSA-1, led to the remodeling of histone landscapes in the genome and thereby attenuated histone acetylation-dependent inflammatory signaling. We also confirmed that RUNX2 was sulfhydrated by administration of NaHS. Collectively, restoration of H 2 S may provide a novel treatment for CBS-deficiency induced metabolic osteoporosis." @default.
- W2897530735 created "2018-10-26" @default.
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- W2897530735 date "2018-10-15" @default.
- W2897530735 modified "2023-10-16" @default.
- W2897530735 title "Hydrogen Sulfide Promotes Bone Homeostasis by Balancing Inflammatory Cytokine Signaling in CBS-Deficient Mice through an Epigenetic Mechanism" @default.
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- W2897530735 doi "https://doi.org/10.1038/s41598-018-33149-9" @default.
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