FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897535402> ?p ?o ?g. }

• W2897535402 abstract "Objective Heat shock proteins (HSPs) are ubiquitously expressed proteins that help preserve cellular homeostasis. Within mammalian skeletal muscle three of the better characterised HSPs are HSP72, HSP27 and αB-crystallin. Among other roles, these three HSPs are involved in regulation of muscle mass and function and may be of importance in ageing. HSP’s are fibre-type dependent in rat skeletal muscle and thus examining these proteins in humans should be completed on the single fibre level, particularly in ageing where maladaptations primarily occur in Type II fibres. High-Intensity Training (HIT) is a commonly used method to improve muscle health and function in the elderly, but HSP adaptability to training has not yet been investigated. &#x0D; Methods This study examined isolated single muscle fibre segments collected from freeze-dried vastus lateralis muscle samples from young (25 /- 3 year old) and older (70 /- 4 year old) healthy individuals. A further sample was collected from the older individuals following 12 weeks of HIT, where they performed 4 x 4 min @ ~90-95% of peak heart rate (HR), with 4 min active recovery at 50-60% peak HR&#x0D; Results Basal expression of HSP’s in skeletal muscle: HSP70 tended to be higher in Type I fibres compared to Type II in young adults (p=0.08) and was higher in Type I compared to Type II fibres of older adults (p=0.03). HSP27 abundance was higher in Type I fibres compared to Type II in young adults (p=0.01) and tended to be higher in Type I compared to Type II fibres in older adults (p=0.07). The abundance of αβ-crystallin was more abundant in Type I fibres compared to Type II in both young and older adults (p<0.05). Preliminary data revealed that the abundance of pABCser59 and pHSP2782 displayed no fibre-type specific abundances in either young or older adults.&#x0D; Age effects on HSP’s: There was no difference in the abundance of HSP70, HSP27, ABC or pHSP2782 between young and older adults in either Type I or Type II fibres. There was an increase in the abundance of pABCser59 in Type I fibres in older adults compared to Type I fibres of young adults (p=0.03), with no difference in Type II fibres.&#x0D; Effects of HIT on HSP’s: HIT in the older individuals increased the abundance of HSP70 in Type I fibres (p<0.01) but not Type II. HIT tended to decrease the abundance of HSP27 in Type I fibres (0.92±0.66, p=0.06) and tended to increase the abundance of αβ-crystallin in Type I fibres (1.03±1.51 p=0.07).&#x0D; Conclusions These results revealed that in healthy, older individuals, the basal levels of HSP27, ABC or pHSP2782 are not different to those in young adults in either Type I or Type II fibres. This could indicate that the muscle from the older individuals was not compromised. Interestingly, in response to HIT there were varying changes between these HSP’s, and of note these occurred only in Type I fibres. Given that during HIT Type II fibres would be activated to a greater extent, it appears that the recovery phases of the HIT were most responsive to HSPs." @default.
• W2897535402 created "2018-10-26" @default.
• W2897535402 creator A5016857230 @default.
• W2897535402 creator A5040206564 @default.
• W2897535402 creator A5043338847 @default.
• W2897535402 creator A5043528134 @default.
• W2897535402 creator A5064060067 @default.
• W2897535402 date "2018-10-03" @default.
• W2897535402 modified "2023-09-26" @default.
• W2897535402 title "PL - 039 Heat Shock Proteins in human single skeletal muscle fibres resist age associated alterations and differentially respond to high-intensity exercise training" @default.
• W2897535402 doi "https://doi.org/10.14428/ebr.v1i1.8573" @default.
• W2897535402 hasPublicationYear "2018" @default.
• W2897535402 type Work @default.
• W2897535402 sameAs 2897535402 @default.
• W2897535402 citedByCount "0" @default.
• W2897535402 crossrefType "journal-article" @default.
• W2897535402 hasAuthorship W2897535402A5016857230 @default.
• W2897535402 hasAuthorship W2897535402A5040206564 @default.
• W2897535402 hasAuthorship W2897535402A5043338847 @default.
• W2897535402 hasAuthorship W2897535402A5043528134 @default.
• W2897535402 hasAuthorship W2897535402A5064060067 @default.
• W2897535402 hasBestOaLocation W28975354021 @default.
• W2897535402 hasConcept C104317684 @default.
• W2897535402 hasConcept C126322002 @default.
• W2897535402 hasConcept C134018914 @default.
• W2897535402 hasConcept C205260736 @default.
• W2897535402 hasConcept C2776643329 @default.
• W2897535402 hasConcept C2779559962 @default.
• W2897535402 hasConcept C2779959927 @default.
• W2897535402 hasConcept C500499127 @default.
• W2897535402 hasConcept C55493867 @default.
• W2897535402 hasConcept C68991219 @default.
• W2897535402 hasConcept C71924100 @default.
• W2897535402 hasConcept C86803240 @default.
• W2897535402 hasConcept C99830354 @default.
• W2897535402 hasConceptScore W2897535402C104317684 @default.
• W2897535402 hasConceptScore W2897535402C126322002 @default.
• W2897535402 hasConceptScore W2897535402C134018914 @default.
• W2897535402 hasConceptScore W2897535402C205260736 @default.
• W2897535402 hasConceptScore W2897535402C2776643329 @default.
• W2897535402 hasConceptScore W2897535402C2779559962 @default.
• W2897535402 hasConceptScore W2897535402C2779959927 @default.
• W2897535402 hasConceptScore W2897535402C500499127 @default.
• W2897535402 hasConceptScore W2897535402C55493867 @default.
• W2897535402 hasConceptScore W2897535402C68991219 @default.
• W2897535402 hasConceptScore W2897535402C71924100 @default.
• W2897535402 hasConceptScore W2897535402C86803240 @default.
• W2897535402 hasConceptScore W2897535402C99830354 @default.
• W2897535402 hasLocation W28975354021 @default.
• W2897535402 hasOpenAccess W2897535402 @default.
• W2897535402 hasPrimaryLocation W28975354021 @default.
• W2897535402 hasRelatedWork W1967876830 @default.
• W2897535402 hasRelatedWork W1972570060 @default.
• W2897535402 hasRelatedWork W1976937132 @default.
• W2897535402 hasRelatedWork W1977383593 @default.
• W2897535402 hasRelatedWork W1992716289 @default.
• W2897535402 hasRelatedWork W1993717575 @default.
• W2897535402 hasRelatedWork W2046112503 @default.
• W2897535402 hasRelatedWork W2182975969 @default.
• W2897535402 hasRelatedWork W2897535402 @default.
• W2897535402 hasRelatedWork W2902555929 @default.
• W2897535402 isParatext "false" @default.
• W2897535402 isRetracted "false" @default.
• W2897535402 magId "2897535402" @default.
• W2897535402 workType "article" @default.