FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897536537> ?p ?o ?g. }

• W2897536537 endingPage "e0205746" @default.
• W2897536537 startingPage "e0205746" @default.
• W2897536537 abstract "Tumor-Infiltrating Lymphocytes (TILs) has been shown to be essential to predict disease outcome in several types of cancers. Moreover, the distribution of cytotoxic T lymphocytes (CD8+) and T cells in general (CD3+) have been used to establish an Immunoscore, as a new cancer prognosticator for survival in colon and lung cancer. In bladder cancer, immune activation has been shown to be associated with genomic subtypes of muscle invasive bladder cancer (MIBC). We sought to evaluate the prognostic impact of these immune cell types in MIBC patients treated with radical cystectomy. For this purpose, cystectomy sections (n = 67) with identifiable invasive margin were selected and stained for CD8+ and CD3+ tumour infiltrating lymphocytes (TILs); both tumor core (CT) and invasive margin (IM) were assessed. Immunoscore was calculated based on previously defined criteria and used to illustrate differences in survival. High density of CD8IM TILs was associated with better disease-free (DFS) (P = 0.01) and overall survival (OS) (P = 0.02) whereas CD3IM TILs were associated with better OS (P = 0.05). Immunoscore was associated with improved DFS (P = 0.02) and OS (P = 0.05). The expression of cytotoxic T cells (CD8+ T cells) in TCGA bladder cancer was also investigated from RNA-Seq profiles of 344 cases. T cell cytotoxicity associated genes (n = 113) were derived from MSig GSEA database. Luminal (n = 121) and basal (n = 68) samples were used to evaluate expression differences. Differential expression (P<0.05) of cytotoxic T cell genes was noted across different molecular subsets of bladder cancer within TCGA analysis. Our data suggests host immune system appears to play a valuable prognostic role in MIBC." @default.
• W2897536537 created "2018-10-26" @default.
• W2897536537 creator A5005468871 @default.
• W2897536537 creator A5015826277 @default.
• W2897536537 creator A5020232745 @default.
• W2897536537 creator A5023126884 @default.
• W2897536537 creator A5048198842 @default.
• W2897536537 creator A5055368367 @default.
• W2897536537 creator A5072587201 @default.
• W2897536537 creator A5083462162 @default.
• W2897536537 creator A5088442918 @default.
• W2897536537 date "2018-10-11" @default.
• W2897536537 modified "2023-09-27" @default.
• W2897536537 title "Presence of lymphocytic infiltrate cytotoxic T lymphocyte CD3+, CD8+, and immunoscore as prognostic marker in patients after radical cystectomy" @default.
• W2897536537 cites W1705518899 @default.
• W2897536537 cites W1859257957 @default.
• W2897536537 cites W1971208896 @default.
• W2897536537 cites W1980808101 @default.
• W2897536537 cites W2010421788 @default.
• W2897536537 cites W2033775272 @default.
• W2897536537 cites W2046731919 @default.
• W2897536537 cites W2051507724 @default.
• W2897536537 cites W2067964015 @default.
• W2897536537 cites W2068523052 @default.
• W2897536537 cites W2071183770 @default.
• W2897536537 cites W2093773243 @default.
• W2897536537 cites W2096151993 @default.
• W2897536537 cites W2101585919 @default.
• W2897536537 cites W2119301589 @default.
• W2897536537 cites W2124614719 @default.
• W2897536537 cites W2133650808 @default.
• W2897536537 cites W2140330371 @default.
• W2897536537 cites W2157824068 @default.
• W2897536537 cites W2166752790 @default.
• W2897536537 cites W2170137783 @default.
• W2897536537 cites W2178105926 @default.
• W2897536537 cites W2234923158 @default.
• W2897536537 cites W2289712604 @default.
• W2897536537 cites W2507880739 @default.
• W2897536537 cites W2744586223 @default.
• W2897536537 cites W2782546217 @default.
• W2897536537 cites W624699035 @default.
• W2897536537 doi "https://doi.org/10.1371/journal.pone.0205746" @default.
• W2897536537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6181418" @default.
• W2897536537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30308033" @default.
• W2897536537 hasPublicationYear "2018" @default.
• W2897536537 type Work @default.
• W2897536537 sameAs 2897536537 @default.
• W2897536537 citedByCount "35" @default.
• W2897536537 countsByYear W28975365372019 @default.
• W2897536537 countsByYear W28975365372020 @default.
• W2897536537 countsByYear W28975365372021 @default.
• W2897536537 countsByYear W28975365372022 @default.
• W2897536537 countsByYear W28975365372023 @default.
• W2897536537 crossrefType "journal-article" @default.
• W2897536537 hasAuthorship W2897536537A5005468871 @default.
• W2897536537 hasAuthorship W2897536537A5015826277 @default.
• W2897536537 hasAuthorship W2897536537A5020232745 @default.
• W2897536537 hasAuthorship W2897536537A5023126884 @default.
• W2897536537 hasAuthorship W2897536537A5048198842 @default.
• W2897536537 hasAuthorship W2897536537A5055368367 @default.
• W2897536537 hasAuthorship W2897536537A5072587201 @default.
• W2897536537 hasAuthorship W2897536537A5083462162 @default.
• W2897536537 hasAuthorship W2897536537A5088442918 @default.
• W2897536537 hasBestOaLocation W28975365371 @default.
• W2897536537 hasConcept C114684123 @default.
• W2897536537 hasConcept C121608353 @default.
• W2897536537 hasConcept C126322002 @default.
• W2897536537 hasConcept C143998085 @default.
• W2897536537 hasConcept C154317977 @default.
• W2897536537 hasConcept C167672396 @default.
• W2897536537 hasConcept C202751555 @default.
• W2897536537 hasConcept C203014093 @default.
• W2897536537 hasConcept C2775910329 @default.
• W2897536537 hasConcept C2778326572 @default.
• W2897536537 hasConcept C2780352672 @default.
• W2897536537 hasConcept C502942594 @default.
• W2897536537 hasConcept C55493867 @default.
• W2897536537 hasConcept C71924100 @default.
• W2897536537 hasConcept C86803240 @default.
• W2897536537 hasConcept C8891405 @default.
• W2897536537 hasConceptScore W2897536537C114684123 @default.
• W2897536537 hasConceptScore W2897536537C121608353 @default.
• W2897536537 hasConceptScore W2897536537C126322002 @default.
• W2897536537 hasConceptScore W2897536537C143998085 @default.
• W2897536537 hasConceptScore W2897536537C154317977 @default.
• W2897536537 hasConceptScore W2897536537C167672396 @default.
• W2897536537 hasConceptScore W2897536537C202751555 @default.
• W2897536537 hasConceptScore W2897536537C203014093 @default.
• W2897536537 hasConceptScore W2897536537C2775910329 @default.
• W2897536537 hasConceptScore W2897536537C2778326572 @default.
• W2897536537 hasConceptScore W2897536537C2780352672 @default.
• W2897536537 hasConceptScore W2897536537C502942594 @default.
• W2897536537 hasConceptScore W2897536537C55493867 @default.
• W2897536537 hasConceptScore W2897536537C71924100 @default.
• W2897536537 hasConceptScore W2897536537C86803240 @default.
• W2897536537 hasConceptScore W2897536537C8891405 @default.
• W2897536537 hasFunder F4320310544 @default.

• next