FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897540388> ?p ?o ?g. }

• W2897540388 endingPage "47" @default.
• W2897540388 startingPage "47" @default.
• W2897540388 abstract "The Strecker reaction of aldehydes with ammonia and hydrogen cyanide first leads to α-aminonitriles, which are then hydrolyzed to α-amino acids. However, before reacting with water, these aminonitriles can be trapped by aminothiols, such as cysteine or homocysteine, to give 5- or 6-membered ring heterocycles, which in turn are hydrolyzed to dipeptides. We propose that this two-step process enabled the formation of thiol-containing dipeptides in the primitive ocean. These small peptides are able to promote the formation of other peptide bonds and of heterocyclic molecules. Theoretical calculations support our experimental results. They predict that α-aminonitriles should be more reactive than other nitriles, and that imidazoles should be formed from transiently formed amidinonitriles. Overall, this set of reactions delineates a possible early stage of the development of organic chemistry, hence of life, on Earth dominated by nitriles and thiol-rich peptides (TRP)." @default.
• W2897540388 created "2018-10-26" @default.
• W2897540388 creator A5013939382 @default.
• W2897540388 creator A5060407639 @default.
• W2897540388 creator A5065908029 @default.
• W2897540388 creator A5066073393 @default.
• W2897540388 creator A5066632182 @default.
• W2897540388 date "2018-10-19" @default.
• W2897540388 modified "2023-10-16" @default.
• W2897540388 title "The Reaction of Aminonitriles with Aminothiols: A Way to Thiol-Containing Peptides and Nitrogen Heterocycles in the Primitive Earth Ocean" @default.
• W2897540388 cites W1548037790 @default.
• W2897540388 cites W1579712812 @default.
• W2897540388 cites W1717117249 @default.
• W2897540388 cites W1965198394 @default.
• W2897540388 cites W1970777413 @default.
• W2897540388 cites W1977404149 @default.
• W2897540388 cites W1979719174 @default.
• W2897540388 cites W1993130196 @default.
• W2897540388 cites W1995253346 @default.
• W2897540388 cites W2000997907 @default.
• W2897540388 cites W2003362129 @default.
• W2897540388 cites W2023856795 @default.
• W2897540388 cites W2033873715 @default.
• W2897540388 cites W2043175828 @default.
• W2897540388 cites W2049116850 @default.
• W2897540388 cites W2052658122 @default.
• W2897540388 cites W2053035518 @default.
• W2897540388 cites W2055327257 @default.
• W2897540388 cites W2060656512 @default.
• W2897540388 cites W2062019095 @default.
• W2897540388 cites W2064049524 @default.
• W2897540388 cites W2068142123 @default.
• W2897540388 cites W2078450884 @default.
• W2897540388 cites W2085158995 @default.
• W2897540388 cites W2101572186 @default.
• W2897540388 cites W2113647774 @default.
• W2897540388 cites W2135893268 @default.
• W2897540388 cites W2165118215 @default.
• W2897540388 cites W2318059402 @default.
• W2897540388 cites W2335572688 @default.
• W2897540388 cites W2512424341 @default.
• W2897540388 cites W2767270522 @default.
• W2897540388 cites W2950424170 @default.
• W2897540388 cites W2951053303 @default.
• W2897540388 cites W1666003599 @default.
• W2897540388 doi "https://doi.org/10.3390/life8040047" @default.
• W2897540388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6316830" @default.
• W2897540388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347745" @default.
• W2897540388 hasPublicationYear "2018" @default.
• W2897540388 type Work @default.
• W2897540388 sameAs 2897540388 @default.
• W2897540388 citedByCount "10" @default.
• W2897540388 countsByYear W28975403882019 @default.
• W2897540388 countsByYear W28975403882020 @default.
• W2897540388 countsByYear W28975403882022 @default.
• W2897540388 countsByYear W28975403882023 @default.
• W2897540388 crossrefType "journal-article" @default.
• W2897540388 hasAuthorship W2897540388A5013939382 @default.
• W2897540388 hasAuthorship W2897540388A5060407639 @default.
• W2897540388 hasAuthorship W2897540388A5065908029 @default.
• W2897540388 hasAuthorship W2897540388A5066073393 @default.
• W2897540388 hasAuthorship W2897540388A5066632182 @default.
• W2897540388 hasBestOaLocation W28975403881 @default.
• W2897540388 hasConcept C146686406 @default.
• W2897540388 hasConcept C161790260 @default.
• W2897540388 hasConcept C178790620 @default.
• W2897540388 hasConcept C181199279 @default.
• W2897540388 hasConcept C185592680 @default.
• W2897540388 hasConcept C21951064 @default.
• W2897540388 hasConcept C2779201268 @default.
• W2897540388 hasConcept C2781046861 @default.
• W2897540388 hasConcept C2781324293 @default.
• W2897540388 hasConcept C31684184 @default.
• W2897540388 hasConcept C32909587 @default.
• W2897540388 hasConcept C515207424 @default.
• W2897540388 hasConcept C5412963 @default.
• W2897540388 hasConcept C55493867 @default.
• W2897540388 hasConcept C94412978 @default.
• W2897540388 hasConceptScore W2897540388C146686406 @default.
• W2897540388 hasConceptScore W2897540388C161790260 @default.
• W2897540388 hasConceptScore W2897540388C178790620 @default.
• W2897540388 hasConceptScore W2897540388C181199279 @default.
• W2897540388 hasConceptScore W2897540388C185592680 @default.
• W2897540388 hasConceptScore W2897540388C21951064 @default.
• W2897540388 hasConceptScore W2897540388C2779201268 @default.
• W2897540388 hasConceptScore W2897540388C2781046861 @default.
• W2897540388 hasConceptScore W2897540388C2781324293 @default.
• W2897540388 hasConceptScore W2897540388C31684184 @default.
• W2897540388 hasConceptScore W2897540388C32909587 @default.
• W2897540388 hasConceptScore W2897540388C515207424 @default.
• W2897540388 hasConceptScore W2897540388C5412963 @default.
• W2897540388 hasConceptScore W2897540388C55493867 @default.
• W2897540388 hasConceptScore W2897540388C94412978 @default.
• W2897540388 hasIssue "4" @default.
• W2897540388 hasLocation W28975403881 @default.
• W2897540388 hasLocation W28975403882 @default.
• W2897540388 hasLocation W28975403883 @default.
• W2897540388 hasLocation W28975403884 @default.

• next