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- W2897542762 abstract "Rapidly progressive dementias (RPD) are considered such, when the cognitive/psyquiatric decline occurs actue/subacute. The time frame to define RPD varies, as well as the different etiologies. Important aspect to consider is potentially reversible causes requiring a prompt treatment. Few case series of RPD are published and information about it is useful in order to allocate healthcare resources. Objective: Describe clinical characteristic and the etiological causes of a series of patients with RPD at our center. An analytical observational cross-sectional study was performed with the information obtained from patients referred to the neurology department. RPD Patients were retrospectively included during 1/12/2009-31/12/2017. We compared baseline clinical, complementary exams, MRI and serologic characteristics. All patients received a comprehensive clinical, laboratory and imaging assessment. ±±15.69years, neurological examination was abnormal in 92.5 %(N=25), with psyquiatric symptoms at onset in 96.3 % (N=26). The median LP-p in the RPD-AI was 53 (16-266), 85 %(N=24) received immunomodulatory treatment. The most common cause of RPD-AI was Leucine Rich glioma 1 (LGi-1). At our center, potentially reversible dementias represented the most frequent etiology underlying RPD. As in other series, this highlights the importance of the thorough evaluation for RPD and start an early treatment upon clinical suspicion when RPD-AI is suspected." @default.
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- W2897542762 date "2018-07-01" @default.
- W2897542762 modified "2023-09-26" @default.
- W2897542762 title "P2‐312: RAPIDLY PROGRESSIVE DEMENTIAS: ETIOLOGIES FOUND IN A HIGH COMPLEXITY REFERRAL CENTER IN BUENOS AIRES" @default.
- W2897542762 doi "https://doi.org/10.1016/j.jalz.2018.06.1002" @default.
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