FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897544150> ?p ?o ?g. }

• W2897544150 abstract "Abstract Realising the potential of human induced pluripotent stem cell (iPSC) technology for drug discovery, disease modelling and cell therapy requires an understanding of variability across iPSC lines. While previous studies have characterized iPS cell lines genetically and transcriptionally, little is known about the variability of the iPSC proteome. Here, we present the first comprehensive proteomic iPSC dataset, analysing 202 iPSC lines derived from 151 donors. We characterise the major genetic determinants affecting proteome and transcriptome variation across iPSC lines and identify key regulatory mechanisms affecting variation in protein abundance. Our data identified >700 human iPSC protein quantitative trait loci (pQTLs). We mapped trans regulatory effects, identifying an important role for protein-protein interactions. We discovered that pQTLs show increased enrichment in disease-linked GWAS variants, compared with RNA-based eQTLs." @default.
• W2897544150 created "2018-10-26" @default.
• W2897544150 creator A5008364714 @default.
• W2897544150 creator A5012730233 @default.
• W2897544150 creator A5030558892 @default.
• W2897544150 creator A5050394882 @default.
• W2897544150 creator A5065781002 @default.
• W2897544150 creator A5082096083 @default.
• W2897544150 creator A5091002491 @default.
• W2897544150 date "2018-10-11" @default.
• W2897544150 modified "2023-09-23" @default.
• W2897544150 title "Population-scale proteome variation in human induced pluripotent stem cells" @default.
• W2897544150 cites W1503104627 @default.
• W2897544150 cites W1817943252 @default.
• W2897544150 cites W1967282907 @default.
• W2897544150 cites W1973268693 @default.
• W2897544150 cites W1986911601 @default.
• W2897544150 cites W2008485310 @default.
• W2897544150 cites W2019983262 @default.
• W2897544150 cites W2028546773 @default.
• W2897544150 cites W2029346581 @default.
• W2897544150 cites W2036321220 @default.
• W2897544150 cites W2041399392 @default.
• W2897544150 cites W2043764521 @default.
• W2897544150 cites W2044286001 @default.
• W2897544150 cites W2048280438 @default.
• W2897544150 cites W2056499061 @default.
• W2897544150 cites W2069440129 @default.
• W2897544150 cites W2073109785 @default.
• W2897544150 cites W2080752012 @default.
• W2897544150 cites W2096217402 @default.
• W2897544150 cites W2104549677 @default.
• W2897544150 cites W2106806242 @default.
• W2897544150 cites W2114104545 @default.
• W2897544150 cites W2114526351 @default.
• W2897544150 cites W2128551987 @default.
• W2897544150 cites W2138207763 @default.
• W2897544150 cites W2148043260 @default.
• W2897544150 cites W2155992983 @default.
• W2897544150 cites W2162426271 @default.
• W2897544150 cites W2165232124 @default.
• W2897544150 cites W2169456326 @default.
• W2897544150 cites W2241686927 @default.
• W2897544150 cites W2292488759 @default.
• W2897544150 cites W2434017435 @default.
• W2897544150 cites W2537623931 @default.
• W2897544150 cites W2544360569 @default.
• W2897544150 cites W2559028527 @default.
• W2897544150 cites W2560543312 @default.
• W2897544150 cites W2562523657 @default.
• W2897544150 cites W2566843361 @default.
• W2897544150 cites W2592811885 @default.
• W2897544150 cites W2604155358 @default.
• W2897544150 cites W2604802828 @default.
• W2897544150 cites W2605339538 @default.
• W2897544150 cites W2613179652 @default.
• W2897544150 cites W2764015132 @default.
• W2897544150 cites W2766450041 @default.
• W2897544150 cites W2805712258 @default.
• W2897544150 cites W2810715813 @default.
• W2897544150 cites W2949644565 @default.
• W2897544150 cites W4250359879 @default.
• W2897544150 doi "https://doi.org/10.1101/439216" @default.
• W2897544150 hasPublicationYear "2018" @default.
• W2897544150 type Work @default.
• W2897544150 sameAs 2897544150 @default.
• W2897544150 citedByCount "5" @default.
• W2897544150 countsByYear W28975441502018 @default.
• W2897544150 countsByYear W28975441502019 @default.
• W2897544150 countsByYear W28975441502020 @default.
• W2897544150 crossrefType "posted-content" @default.
• W2897544150 hasAuthorship W2897544150A5008364714 @default.
• W2897544150 hasAuthorship W2897544150A5012730233 @default.
• W2897544150 hasAuthorship W2897544150A5030558892 @default.
• W2897544150 hasAuthorship W2897544150A5050394882 @default.
• W2897544150 hasAuthorship W2897544150A5065781002 @default.
• W2897544150 hasAuthorship W2897544150A5082096083 @default.
• W2897544150 hasAuthorship W2897544150A5091002491 @default.
• W2897544150 hasBestOaLocation W28975441501 @default.
• W2897544150 hasConcept C104317684 @default.
• W2897544150 hasConcept C104397665 @default.
• W2897544150 hasConcept C106208931 @default.
• W2897544150 hasConcept C107459253 @default.
• W2897544150 hasConcept C135763542 @default.
• W2897544150 hasConcept C144024400 @default.
• W2897544150 hasConcept C145103041 @default.
• W2897544150 hasConcept C149923435 @default.
• W2897544150 hasConcept C150194340 @default.
• W2897544150 hasConcept C153209595 @default.
• W2897544150 hasConcept C162317418 @default.
• W2897544150 hasConcept C168393362 @default.
• W2897544150 hasConcept C2908647359 @default.
• W2897544150 hasConcept C46111723 @default.
• W2897544150 hasConcept C54355233 @default.
• W2897544150 hasConcept C68873052 @default.
• W2897544150 hasConcept C70721500 @default.
• W2897544150 hasConcept C86803240 @default.
• W2897544150 hasConceptScore W2897544150C104317684 @default.
• W2897544150 hasConceptScore W2897544150C104397665 @default.
• W2897544150 hasConceptScore W2897544150C106208931 @default.

• next