FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897544259> ?p ?o ?g. }

• W2897544259 endingPage "1020.e2" @default.
• W2897544259 startingPage "1012" @default.
• W2897544259 abstract "BackgroundSuboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.ObjectiveWe sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.MethodsBy using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.ResultsAt 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.ConclusionThis study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life. Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes. We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development. By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age. At 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands. This study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life." @default.
• W2897544259 created "2018-10-26" @default.
• W2897544259 creator A5011937215 @default.
• W2897544259 creator A5038952781 @default.
• W2897544259 creator A5039039906 @default.
• W2897544259 creator A5040798989 @default.
• W2897544259 creator A5044718208 @default.
• W2897544259 creator A5060506534 @default.
• W2897544259 creator A5077492180 @default.
• W2897544259 creator A5089611352 @default.
• W2897544259 date "2019-03-01" @default.
• W2897544259 modified "2023-10-17" @default.
• W2897544259 title "Direct infant UV light exposure is associated with eczema and immune development" @default.
• W2897544259 cites W1529615153 @default.
• W2897544259 cites W1596396287 @default.
• W2897544259 cites W1663317712 @default.
• W2897544259 cites W1964215386 @default.
• W2897544259 cites W1966383156 @default.
• W2897544259 cites W1969117799 @default.
• W2897544259 cites W1976665465 @default.
• W2897544259 cites W1993426597 @default.
• W2897544259 cites W1993800741 @default.
• W2897544259 cites W1998682199 @default.
• W2897544259 cites W2018685662 @default.
• W2897544259 cites W2029658399 @default.
• W2897544259 cites W2036586400 @default.
• W2897544259 cites W2048932980 @default.
• W2897544259 cites W2057220610 @default.
• W2897544259 cites W2071165175 @default.
• W2897544259 cites W2072267068 @default.
• W2897544259 cites W2085063771 @default.
• W2897544259 cites W2095422531 @default.
• W2897544259 cites W2108279958 @default.
• W2897544259 cites W2114059803 @default.
• W2897544259 cites W2117580741 @default.
• W2897544259 cites W2124605368 @default.
• W2897544259 cites W2155649257 @default.
• W2897544259 cites W2157343653 @default.
• W2897544259 cites W2170133547 @default.
• W2897544259 cites W2254958366 @default.
• W2897544259 cites W2263094600 @default.
• W2897544259 cites W2318159813 @default.
• W2897544259 cites W2769887687 @default.
• W2897544259 cites W4313309969 @default.
• W2897544259 doi "https://doi.org/10.1016/j.jaci.2018.08.037" @default.
• W2897544259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366577" @default.
• W2897544259 hasPublicationYear "2019" @default.
• W2897544259 type Work @default.
• W2897544259 sameAs 2897544259 @default.
• W2897544259 citedByCount "39" @default.
• W2897544259 countsByYear W28975442592018 @default.
• W2897544259 countsByYear W28975442592019 @default.
• W2897544259 countsByYear W28975442592020 @default.
• W2897544259 countsByYear W28975442592021 @default.
• W2897544259 countsByYear W28975442592022 @default.
• W2897544259 countsByYear W28975442592023 @default.
• W2897544259 crossrefType "journal-article" @default.
• W2897544259 hasAuthorship W2897544259A5011937215 @default.
• W2897544259 hasAuthorship W2897544259A5038952781 @default.
• W2897544259 hasAuthorship W2897544259A5039039906 @default.
• W2897544259 hasAuthorship W2897544259A5040798989 @default.
• W2897544259 hasAuthorship W2897544259A5044718208 @default.
• W2897544259 hasAuthorship W2897544259A5060506534 @default.
• W2897544259 hasAuthorship W2897544259A5077492180 @default.
• W2897544259 hasAuthorship W2897544259A5089611352 @default.
• W2897544259 hasBestOaLocation W28975442591 @default.
• W2897544259 hasConcept C119060515 @default.
• W2897544259 hasConcept C126322002 @default.
• W2897544259 hasConcept C203014093 @default.
• W2897544259 hasConcept C2776940978 @default.
• W2897544259 hasConcept C71924100 @default.
• W2897544259 hasConcept C8891405 @default.
• W2897544259 hasConcept C90924648 @default.
• W2897544259 hasConceptScore W2897544259C119060515 @default.
• W2897544259 hasConceptScore W2897544259C126322002 @default.
• W2897544259 hasConceptScore W2897544259C203014093 @default.
• W2897544259 hasConceptScore W2897544259C2776940978 @default.
• W2897544259 hasConceptScore W2897544259C71924100 @default.
• W2897544259 hasConceptScore W2897544259C8891405 @default.
• W2897544259 hasConceptScore W2897544259C90924648 @default.
• W2897544259 hasFunder F4320311925 @default.
• W2897544259 hasFunder F4320320470 @default.
• W2897544259 hasIssue "3" @default.
• W2897544259 hasLocation W28975442591 @default.
• W2897544259 hasLocation W28975442592 @default.
• W2897544259 hasOpenAccess W2897544259 @default.
• W2897544259 hasPrimaryLocation W28975442591 @default.
• W2897544259 hasRelatedWork W2126365059 @default.
• W2897544259 hasRelatedWork W2487490720 @default.
• W2897544259 hasRelatedWork W2606644627 @default.
• W2897544259 hasRelatedWork W2793077515 @default.
• W2897544259 hasRelatedWork W2980097659 @default.
• W2897544259 hasRelatedWork W2981615369 @default.
• W2897544259 hasRelatedWork W3048651736 @default.
• W2897544259 hasRelatedWork W3130621552 @default.
• W2897544259 hasRelatedWork W4292573045 @default.
• W2897544259 hasRelatedWork W4386009577 @default.
• W2897544259 hasVolume "143" @default.

• next