FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897545107> ?p ?o ?g. }

• W2897545107 endingPage "319" @default.
• W2897545107 startingPage "312" @default.
• W2897545107 abstract "Ketamine acts as a rapid-acting antidepressant by restoring glutamatergic deficits and activating synaptic plasticity processes, with peak activity 24 h after infusion. Microtubule dynamics are known to play a key role in modulation of cytoskeleton and synaptic plasticity, as well as in signalling events in peripheral blood cells. Here, we correlated ketamine-induced change in glutamate/creatinine (Glu/Cr) levels in the pregenual anterior cingulate cortex (pgACC) with peripheral markers of microtubule dynamics, namely acetylated α-tubulin (Acet-Tub), with particular attention to gender specificity. Eighty healthy controls (age = 25.89 ± 5.29, 33 women) were administered intravenous infusion of either ketamine (0.5 mg/kg) or placebo (saline). Blood samples were obtained at baseline and 24 h after infusion and plasma levels of Acet-Tub and transferrin (TRF; loading control) were measured via infrared western blotting. Glu/Cr levels were measured via high-field (7 T) proton magnetic resonance spectroscopy [1H-MRS] in the pgACC at the same time points. Gender differences were observed in baseline Acet-Tub/TRF levels (p < 0.001), and an interaction of time by treatment by gender (F = 5.13, p = 0.027) was found, with a significant increase in Acet-Tub/TRF for ketamine group in females only (p = 0.038). Ketamine-induced gender-independent Glu/Cr changes at 24 h (F(1, 69) = 4.08, p = 0.047), and changes in the pgACC were negatively correlated with the Acet-Tub/TRF expression (r= -0.464, p = 0.010) in the ketamine group, in which, separated by sex, only women showed significant correlation. Our findings indicate a temporal association between changes in central ketamine-induced glutamatergic effects and peripheral markers of cytoskeleton reorganization, particularly in females." @default.
• W2897545107 created "2018-10-26" @default.
• W2897545107 creator A5002829279 @default.
• W2897545107 creator A5002985304 @default.
• W2897545107 creator A5020881115 @default.
• W2897545107 creator A5022718112 @default.
• W2897545107 creator A5026964915 @default.
• W2897545107 creator A5049463715 @default.
• W2897545107 creator A5055725293 @default.
• W2897545107 creator A5086602752 @default.
• W2897545107 creator A5087655756 @default.
• W2897545107 creator A5089195120 @default.
• W2897545107 date "2019-02-01" @default.
• W2897545107 modified "2023-10-09" @default.
• W2897545107 title "Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects" @default.
• W2897545107 cites W1639119719 @default.
• W2897545107 cites W1730237872 @default.
• W2897545107 cites W1846441878 @default.
• W2897545107 cites W1877874306 @default.
• W2897545107 cites W1969328491 @default.
• W2897545107 cites W1974403366 @default.
• W2897545107 cites W1989737463 @default.
• W2897545107 cites W1995221679 @default.
• W2897545107 cites W1996941358 @default.
• W2897545107 cites W2000022451 @default.
• W2897545107 cites W2003144714 @default.
• W2897545107 cites W2003303711 @default.
• W2897545107 cites W2008172722 @default.
• W2897545107 cites W2011464940 @default.
• W2897545107 cites W2013294274 @default.
• W2897545107 cites W2014112958 @default.
• W2897545107 cites W2014466762 @default.
• W2897545107 cites W2017331060 @default.
• W2897545107 cites W2018114814 @default.
• W2897545107 cites W2018173306 @default.
• W2897545107 cites W2023081218 @default.
• W2897545107 cites W2024251150 @default.
• W2897545107 cites W2030446659 @default.
• W2897545107 cites W2040344668 @default.
• W2897545107 cites W2043038896 @default.
• W2897545107 cites W2049225918 @default.
• W2897545107 cites W2052665050 @default.
• W2897545107 cites W2059916086 @default.
• W2897545107 cites W2068026567 @default.
• W2897545107 cites W2077129553 @default.
• W2897545107 cites W2086656730 @default.
• W2897545107 cites W2089351762 @default.
• W2897545107 cites W2095018794 @default.
• W2897545107 cites W2105815100 @default.
• W2897545107 cites W2109334244 @default.
• W2897545107 cites W2121208257 @default.
• W2897545107 cites W2131421588 @default.
• W2897545107 cites W2133499169 @default.
• W2897545107 cites W2133688354 @default.
• W2897545107 cites W2136433713 @default.
• W2897545107 cites W2150459980 @default.
• W2897545107 cites W2154349372 @default.
• W2897545107 cites W2164793526 @default.
• W2897545107 cites W2208668986 @default.
• W2897545107 cites W2222046008 @default.
• W2897545107 cites W2291443053 @default.
• W2897545107 cites W2308910221 @default.
• W2897545107 cites W2317184793 @default.
• W2897545107 cites W2336977282 @default.
• W2897545107 cites W2344505457 @default.
• W2897545107 cites W2495579837 @default.
• W2897545107 cites W2518536270 @default.
• W2897545107 cites W2529017560 @default.
• W2897545107 cites W2554643912 @default.
• W2897545107 cites W2595110790 @default.
• W2897545107 cites W2601585445 @default.
• W2897545107 cites W2732930884 @default.
• W2897545107 cites W2770049007 @default.
• W2897545107 cites W2796261668 @default.
• W2897545107 cites W2801270486 @default.
• W2897545107 cites W2803958441 @default.
• W2897545107 doi "https://doi.org/10.1016/j.bbr.2018.10.021" @default.
• W2897545107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30342064" @default.
• W2897545107 hasPublicationYear "2019" @default.
• W2897545107 type Work @default.
• W2897545107 sameAs 2897545107 @default.
• W2897545107 citedByCount "9" @default.
• W2897545107 countsByYear W28975451072019 @default.
• W2897545107 countsByYear W28975451072020 @default.
• W2897545107 countsByYear W28975451072021 @default.
• W2897545107 countsByYear W28975451072022 @default.
• W2897545107 countsByYear W28975451072023 @default.
• W2897545107 crossrefType "journal-article" @default.
• W2897545107 hasAuthorship W2897545107A5002829279 @default.
• W2897545107 hasAuthorship W2897545107A5002985304 @default.
• W2897545107 hasAuthorship W2897545107A5020881115 @default.
• W2897545107 hasAuthorship W2897545107A5022718112 @default.
• W2897545107 hasAuthorship W2897545107A5026964915 @default.
• W2897545107 hasAuthorship W2897545107A5049463715 @default.
• W2897545107 hasAuthorship W2897545107A5055725293 @default.
• W2897545107 hasAuthorship W2897545107A5086602752 @default.
• W2897545107 hasAuthorship W2897545107A5087655756 @default.
• W2897545107 hasAuthorship W2897545107A5089195120 @default.

• next