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• W2897545222 abstract "Significance T immune cells can be engineered to express tumor-specific T cell receptor (TCR) genes and thereby kill cancer cells. This approach—termed TCR gene therapy—is effective but can cause serious adverse events if the target is also expressed in healthy, noncancerous tissue. NY-ESO-1 is a tumor-specific antigen that has been targeted successfully and safely through TCR gene therapies for melanoma, synovial sarcoma, and myeloma. However, trials to date have focused exclusively on a single NY-ESO-1–derived epitope presented on HLA-A*02:01, limiting application to patients expressing that allele. In this work, we isolate TCRs that collectively recognize multiple NY-ESO-1–derived epitopes presented by multiple MHC alleles. We thereby outline a general approach for expanding targeted immunotherapies to more diverse MHC haplotypes." @default.
• W2897545222 created "2018-10-26" @default.
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• W2897545222 date "2018-10-22" @default.
• W2897545222 modified "2023-10-15" @default.
• W2897545222 title "Isolation and characterization of NY-ESO-1–specific T cell receptors restricted on various MHC molecules" @default.
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• W2897545222 doi "https://doi.org/10.1073/pnas.1810653115" @default.
• W2897545222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6233129" @default.
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• W2897545222 hasPublicationYear "2018" @default.
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