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• W2897550585 startingPage "349" @default.
• W2897550585 abstract "As recently as 10 years ago, a diagnosis of metastatic melanoma was considered fatal, with a prognosis of typically 6 months or less from diagnosis. The development of checkpoint inhibitors, such as ipilimumab and nivolumab, which modulate the effects of the CTLA-4 and PD-1, respectively, has revolutionized outcomes for these patients. Monotherapy improves metastatic disease survival, but dual therapy provides greater benefit with 58% of patients alive at 3 years. Combination immunotherapy is even active in brain metastases. In the adjuvant setting, data show that at 1 year over 70% patients remain disease-free with PD-1 blockade. Immunotherapy is generally safe and well tolerated. However, treatment-related endocrinopathies require long-term medications. Nowadays, advanced cutaneous melanoma is a more manageable disease." @default.
• W2897550585 created "2018-10-26" @default.
• W2897550585 creator A5056507476 @default.
• W2897550585 creator A5067043341 @default.
• W2897550585 date "2019-02-01" @default.
• W2897550585 modified "2023-10-18" @default.
• W2897550585 title "Nivolumab and ipilimumab: immunotherapy for treatment of malignant melanoma" @default.
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• W2897550585 doi "https://doi.org/10.2217/fon-2018-0607" @default.
• W2897550585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30334646" @default.
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