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- W2897551293 abstract "Enlarged perivascular spaces (PVS) have been recognized as a marker of small vessel disease (SVD). The relationship between PVS and cognition over time is not fully known. The presence of PVS in the HP, basal ganglia (BG) and centrum semiovale (CSO) as well as of white matter lesions (WML) was visually assessed using 3D T1-weighted and FLAIR images in 499 cognitively healthy elderly and 240 individuals with minor cognitive impairment from the BioFINDER study (www.biofinder.se). There was a significant association between cognitive decline and PVS in the HP after two years (β=1.106, p=0.044) years and even stronger after four years (β=2.746, p=0.016); models were adjusted for age, gender, diagnosis and HP volume. In the people with MCI, we found a strong association between PVS and WML in all three locations (OR 1.45 (CSO), 1.43 (BG) and 1.29 (HP), P < 0.001), but no association between PVS and amyloid deposition (CSF or PET); models were adjusted for age, gender and diagnosis. While PVS were strongly associated with markers of cerebral small vessel disease and not with amyloid deposition, PVS in the hippocampus were associated with cognitive decline at follow up." @default.
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- W2897551293 date "2018-07-01" @default.
- W2897551293 modified "2023-10-16" @default.
- W2897551293 title "P1‐422: PERIVASCULAR SPACES IN THE HIPPOCAMPUS ARE ASSOCIATED WITH COGNITIVE DECLINE AT FOUR‐YEAR FOLLOW‐UP IN MCI PATIENTS" @default.
- W2897551293 doi "https://doi.org/10.1016/j.jalz.2018.06.431" @default.
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