Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897551311> ?p ?o ?g. }
- W2897551311 endingPage "3205" @default.
- W2897551311 startingPage "3205" @default.
- W2897551311 abstract "Gestational diabetes mellitus (GDM) is a complex condition that involves a variety of pathological mechanisms, including pancreatic β-cell failure, insulin resistance, and inflammation. There is an increasing body of literature suggesting that these interrelated phenomena may arise from the common mechanism of endoplasmic reticulum (ER) stress. Both obesity-associated nutrient excess and hyperglycemia disturb ER function in protein folding and transport. This results in the accumulation of polypeptides in the ER lumen and impairs insulin secretion and signaling. Exercise elicits metabolic adaptive responses, which may help to restore normal chaperone expression in insulin-resistant tissues. Pharmacological induction of chaperones, mimicking the metabolic effect of exercise, is a promising therapeutic tool for preventing GDM by maintaining the body’s natural stress response. Metformin, a commonly used diabetes medication, has recently been identified as a modulator of ER-stress-associated inflammation. The results of recent studies suggest the potential use of chemical ER chaperones and antioxidant vitamins as therapeutic interventions that can prevent glucose-induced ER stress in GDM placentas. In this review, we discuss whether chaperones may significantly contribute to the pathogenesis of GDM, as well as whether they can be a potential therapeutic target in GDM treatment." @default.
- W2897551311 created "2018-10-26" @default.
- W2897551311 creator A5016361006 @default.
- W2897551311 creator A5031619166 @default.
- W2897551311 creator A5042881462 @default.
- W2897551311 creator A5045138665 @default.
- W2897551311 creator A5046014580 @default.
- W2897551311 creator A5051946243 @default.
- W2897551311 date "2018-10-17" @default.
- W2897551311 modified "2023-10-16" @default.
- W2897551311 title "Heat Shock Proteins as a Potential Therapeutic Target in the Treatment of Gestational Diabetes Mellitus: What We Know so Far" @default.
- W2897551311 cites W1250213387 @default.
- W2897551311 cites W1573357765 @default.
- W2897551311 cites W1619199252 @default.
- W2897551311 cites W1841288895 @default.
- W2897551311 cites W1966937810 @default.
- W2897551311 cites W1973061822 @default.
- W2897551311 cites W1975136933 @default.
- W2897551311 cites W1989379980 @default.
- W2897551311 cites W1995694673 @default.
- W2897551311 cites W2007078899 @default.
- W2897551311 cites W2012248291 @default.
- W2897551311 cites W2013331748 @default.
- W2897551311 cites W2015634373 @default.
- W2897551311 cites W2022592177 @default.
- W2897551311 cites W2026357888 @default.
- W2897551311 cites W2031267215 @default.
- W2897551311 cites W2037194548 @default.
- W2897551311 cites W2038469447 @default.
- W2897551311 cites W2039742351 @default.
- W2897551311 cites W2040377780 @default.
- W2897551311 cites W2043098451 @default.
- W2897551311 cites W2043433277 @default.
- W2897551311 cites W2045488762 @default.
- W2897551311 cites W2048456744 @default.
- W2897551311 cites W2053972428 @default.
- W2897551311 cites W2054530178 @default.
- W2897551311 cites W2056895025 @default.
- W2897551311 cites W2058184727 @default.
- W2897551311 cites W2059410247 @default.
- W2897551311 cites W2060078714 @default.
- W2897551311 cites W2060442023 @default.
- W2897551311 cites W2060574598 @default.
- W2897551311 cites W2064176741 @default.
- W2897551311 cites W2065254980 @default.
- W2897551311 cites W2071136213 @default.
- W2897551311 cites W2074076323 @default.
- W2897551311 cites W2076978440 @default.
- W2897551311 cites W2077572448 @default.
- W2897551311 cites W2078711922 @default.
- W2897551311 cites W2079643102 @default.
- W2897551311 cites W2083278923 @default.
- W2897551311 cites W2084299228 @default.
- W2897551311 cites W2087477704 @default.
- W2897551311 cites W2088248157 @default.
- W2897551311 cites W2088699936 @default.
- W2897551311 cites W2093155745 @default.
- W2897551311 cites W2095708309 @default.
- W2897551311 cites W2103887497 @default.
- W2897551311 cites W2120242770 @default.
- W2897551311 cites W2120275506 @default.
- W2897551311 cites W2125852509 @default.
- W2897551311 cites W2130714174 @default.
- W2897551311 cites W2138664804 @default.
- W2897551311 cites W2138852445 @default.
- W2897551311 cites W2146712490 @default.
- W2897551311 cites W2147592021 @default.
- W2897551311 cites W2152235681 @default.
- W2897551311 cites W2155185645 @default.
- W2897551311 cites W2157386619 @default.
- W2897551311 cites W2158563216 @default.
- W2897551311 cites W2162695817 @default.
- W2897551311 cites W2165266278 @default.
- W2897551311 cites W2192080449 @default.
- W2897551311 cites W2238434403 @default.
- W2897551311 cites W2274487043 @default.
- W2897551311 cites W2282402263 @default.
- W2897551311 cites W2283933805 @default.
- W2897551311 cites W2293229238 @default.
- W2897551311 cites W2318976814 @default.
- W2897551311 cites W2463903199 @default.
- W2897551311 cites W2469797279 @default.
- W2897551311 cites W2577350081 @default.
- W2897551311 cites W2583657457 @default.
- W2897551311 cites W2736584492 @default.
- W2897551311 cites W2772134117 @default.
- W2897551311 cites W2802499980 @default.
- W2897551311 cites W2809225164 @default.
- W2897551311 cites W2809345184 @default.
- W2897551311 cites W2884801135 @default.
- W2897551311 cites W2891824314 @default.
- W2897551311 cites W4213092833 @default.
- W2897551311 cites W4240079238 @default.
- W2897551311 doi "https://doi.org/10.3390/ijms19103205" @default.
- W2897551311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213996" @default.
- W2897551311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30336561" @default.
- W2897551311 hasPublicationYear "2018" @default.
- W2897551311 type Work @default.