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• W2897556827 abstract "Cancer cell migration through and away from tumors is driven in part by migration along aligned extracellular matrix, a process known as contact guidance (CG). To concurrently study the influence of architectural and mechanical regulators of CG sensing, we developed a set of CG platforms. Using flat and nanotextured substrates with variable architectures and stiffness, we show that CG sensing is regulated by substrate stiffness and define a mechanical role for microtubules and actomyosin-microtubule interactions during CG sensing. Furthermore, we show that Arp2/3-dependent lamellipodia dynamics can compete with aligned protrusions to diminish the CG response and define Arp2/3- and Formins-dependent actin architectures that regulate microtubule-dependent protrusions, which promote the CG response. Thus, our work represents a comprehensive examination of the physical mechanisms influencing CG sensing." @default.
• W2897556827 created "2018-10-26" @default.
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• W2897556827 date "2018-10-01" @default.
• W2897556827 modified "2023-10-18" @default.
• W2897556827 title "Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing" @default.
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• W2897556827 doi "https://doi.org/10.1016/j.celrep.2018.09.030" @default.
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