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- W2897557611 endingPage "4447" @default.
- W2897557611 startingPage "4436" @default.
- W2897557611 abstract "Hepatocellular carcinoma (HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management." @default.
- W2897557611 created "2018-10-26" @default.
- W2897557611 creator A5003993820 @default.
- W2897557611 creator A5033595772 @default.
- W2897557611 creator A5079297632 @default.
- W2897557611 creator A5091795929 @default.
- W2897557611 date "2018-10-21" @default.
- W2897557611 modified "2023-10-15" @default.
- W2897557611 title "Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer" @default.
- W2897557611 cites W1174036299 @default.
- W2897557611 cites W1493921738 @default.
- W2897557611 cites W1497368334 @default.
- W2897557611 cites W1507199808 @default.
- W2897557611 cites W1518469225 @default.
- W2897557611 cites W1540067925 @default.
- W2897557611 cites W1757407923 @default.
- W2897557611 cites W1795451786 @default.
- W2897557611 cites W1871903510 @default.
- W2897557611 cites W1883333379 @default.
- W2897557611 cites W1964359747 @default.
- W2897557611 cites W1965149282 @default.
- W2897557611 cites W1968569540 @default.
- W2897557611 cites W1971837077 @default.
- W2897557611 cites W1975053453 @default.
- W2897557611 cites W1975154077 @default.
- W2897557611 cites W1976757588 @default.
- W2897557611 cites W1989428407 @default.
- W2897557611 cites W1993211204 @default.
- W2897557611 cites W2000315116 @default.
- W2897557611 cites W2000463136 @default.
- W2897557611 cites W2009671859 @default.
- W2897557611 cites W2016828736 @default.
- W2897557611 cites W2018267029 @default.
- W2897557611 cites W2018328995 @default.
- W2897557611 cites W2023722200 @default.
- W2897557611 cites W2026475551 @default.
- W2897557611 cites W2028316654 @default.
- W2897557611 cites W2039675240 @default.
- W2897557611 cites W2041989558 @default.
- W2897557611 cites W2044422127 @default.
- W2897557611 cites W2051300948 @default.
- W2897557611 cites W2052165023 @default.
- W2897557611 cites W2052329251 @default.
- W2897557611 cites W2052730188 @default.
- W2897557611 cites W2056376549 @default.
- W2897557611 cites W2057698117 @default.
- W2897557611 cites W2058435509 @default.
- W2897557611 cites W2058729436 @default.
- W2897557611 cites W2059688175 @default.
- W2897557611 cites W2060423420 @default.
- W2897557611 cites W2062786616 @default.
- W2897557611 cites W2066667772 @default.
- W2897557611 cites W2068084277 @default.
- W2897557611 cites W2069076782 @default.
- W2897557611 cites W2071476028 @default.
- W2897557611 cites W2076642394 @default.
- W2897557611 cites W2077433243 @default.
- W2897557611 cites W2077684198 @default.
- W2897557611 cites W2079241145 @default.
- W2897557611 cites W2080998956 @default.
- W2897557611 cites W2084722601 @default.
- W2897557611 cites W2085153086 @default.
- W2897557611 cites W2089760642 @default.
- W2897557611 cites W2090925778 @default.
- W2897557611 cites W2092268793 @default.
- W2897557611 cites W2094514571 @default.
- W2897557611 cites W2096166085 @default.
- W2897557611 cites W2097059462 @default.
- W2897557611 cites W2098477897 @default.
- W2897557611 cites W2101084712 @default.
- W2897557611 cites W2107939830 @default.
- W2897557611 cites W2119190881 @default.
- W2897557611 cites W2131109099 @default.
- W2897557611 cites W2132692852 @default.
- W2897557611 cites W2136095967 @default.
- W2897557611 cites W2137052325 @default.
- W2897557611 cites W2152027636 @default.
- W2897557611 cites W2154239359 @default.
- W2897557611 cites W2159151230 @default.
- W2897557611 cites W2164505583 @default.
- W2897557611 cites W2168472139 @default.
- W2897557611 cites W2171925512 @default.
- W2897557611 cites W2173632235 @default.
- W2897557611 cites W2182832569 @default.
- W2897557611 cites W2197145779 @default.
- W2897557611 cites W2261020375 @default.
- W2897557611 cites W2290207881 @default.
- W2897557611 cites W2313623166 @default.
- W2897557611 cites W2335913920 @default.
- W2897557611 cites W2522782769 @default.
- W2897557611 cites W2535633630 @default.
- W2897557611 cites W2552432336 @default.
- W2897557611 cites W2560499218 @default.
- W2897557611 cites W2568306867 @default.
- W2897557611 cites W2582578898 @default.
- W2897557611 cites W2588964480 @default.
- W2897557611 cites W2591717879 @default.
- W2897557611 cites W2606367731 @default.