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- W2897558712 abstract "5230 Currently there are no serum biomarkers for glioblastoma multiforme (GBM) and no simple method exists for following the disease course in patients to test new therapies. In previous studies, we have shown that there are major differences in the protein expression patterns in the tumors of GBM patients that correlated with T1-weighted contrast-enhanced magnetic resonance images (CE-MRI). Tissue samples obtained from contrast-enhanced and nonenhanced tumor regions showed differential genomic expression patterns and qualitative and semiquantitative proteomic pattern differences. We hypothesized that the breakdown of the blood-brain barrier coupled with the high vascularity of GBM would lead to changes in the serum proteome that we could detect using surface enhanced laser desorption/ionization time of flight mass spectroscopy (SELDI-TOF-MS). In this study, we examined the low molecular weight serum peptides (" @default.
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- W2897558712 date "2004-04-01" @default.
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- W2897558712 title "Proteomics of human glioblastoma multiforme: Correlation of serum proteomic patterns to tissue proteomic patterns and magnetic resonance imaging" @default.
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