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• W2897560405 abstract "Abstract Treatment response to antipsychotic drugs is variable and conflicting results have been obtained while studying the influence of DRD 2 and HTR 2 genetic variants on antipsychotic drug efficacy. To explore further, the present study aimed to assess the influence of DRD 2 ‐141 C Ins/Del, Taq1A and HTR 2A ‐1438 G/A, 102T/C and HTR 2C ‐759 C/T genetic polymorphisms in response to risperidone in patients with schizophrenia. The study was conducted among the n = 320 South Indian patients with schizophrenia who received risperidone treatment (4–8 mg per day) for a minimum of four weeks. Genotyping was done by real‐time PCR . Antipsychotic response was assessed using CGI ‐I score in cross‐sectional group, PANSS score in prospective group at baseline and after receiving the risperidone therapy. DRD 2 ‐141 C Ins/Del ( n = 310, Ins/Ins = 177, Ins/Del+ Del/Del = 133, OR 0.70, 95% CI 0.4–1.2 p 0.2), Taq1A ( n = 320, AA = 35, AG = 132, GG = 153, p 0.2), HTR 2A ‐ 1438 G/A ( n = 320, AA = 39, AG = 164, GG = 117, p 0.2), HTR 2A 102T/C ( n = 320, CC = 115, CT = 165, TT = 40, p 0.1) HTR 2C ‐ 759 C/T (females n = 132, CC = 65, CT + TT = 67, OR 1.3, 95% CI 0.6–2.8, p 0.5; males n = 186, C = 120, T = 66, OR 1.2, 95% CI 0.6–2.4, p 0.4) genetic polymorphisms did not show any association with antipsychotic response to risperidone. DRD 2 ‐141 C Ins/Del, Taq1A, HTR 2A ‐1438 G/A, 102T/C and HTR 2C ‐759 C/T genetic variants are not associated with antipsychotic response to risperidone." @default.
• W2897560405 created "2018-10-26" @default.
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• W2897560405 date "2018-11-21" @default.
• W2897560405 modified "2023-10-17" @default.
• W2897560405 title "Dopamine ( <i> <scp>DRD</scp> 2 </i> ) and Serotonin ( <i> <scp>HTR</scp> 2A, 2C) </i> Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia" @default.
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• W2897560405 doi "https://doi.org/10.1111/fcp.12424" @default.
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