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- W2897561902 startingPage "e0213665" @default.
- W2897561902 abstract "The Glucose-Insulin-Glucagon nonlinear model [1-4] accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either insulin (monotherapy) or insulin and glucagon (dual therapy) that can optimally maintain the blood glucose level within desired limits after consumption of a meal and prevent the onset of both hypoglycemia and hyperglycemia. This problem is formulated as a nonlinear optimal control problem, which we solve using the numerical optimal control package PSOPT. Interestingly, in the case of monotherapy, we find the optimal solution is close to the standard method of insulin based glucose regulation, which is to assume a variable amount of insulin half an hour before each meal. We also find that the optimal dual therapy (that uses both insulin and glucagon) is better able to regulate glucose as compared to using insulin alone. We also propose an ad-hoc rule for both the dosage and the time of delivery of insulin and glucagon." @default.
- W2897561902 created "2018-10-26" @default.
- W2897561902 creator A5028047908 @default.
- W2897561902 creator A5034065247 @default.
- W2897561902 creator A5078340993 @default.
- W2897561902 creator A5087023285 @default.
- W2897561902 creator A5091502239 @default.
- W2897561902 date "2019-03-20" @default.
- W2897561902 modified "2023-09-30" @default.
- W2897561902 title "Optimal regulation of blood glucose level in Type I diabetes using insulin and glucagon" @default.
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- W2897561902 cites W1827070843 @default.
- W2897561902 cites W1964693647 @default.
- W2897561902 cites W1966362654 @default.
- W2897561902 cites W1976578688 @default.
- W2897561902 cites W1977797609 @default.
- W2897561902 cites W1980336667 @default.
- W2897561902 cites W1982821381 @default.
- W2897561902 cites W2004575876 @default.
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- W2897561902 cites W2042045847 @default.
- W2897561902 cites W2050297862 @default.
- W2897561902 cites W2057692796 @default.
- W2897561902 cites W2060091529 @default.
- W2897561902 cites W2061499020 @default.
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- W2897561902 cites W2340309723 @default.
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- W2897561902 cites W269914886 @default.
- W2897561902 cites W2754930286 @default.
- W2897561902 cites W2766574732 @default.
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- W2897561902 doi "https://doi.org/10.1371/journal.pone.0213665" @default.
- W2897561902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6426249" @default.
- W2897561902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30893335" @default.
- W2897561902 hasPublicationYear "2019" @default.
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