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- W2897563186 abstract "The chance discovery of a new group of medicines called nonsteroidal anti-estrogens opened the door to new opportunities in therapeutics. Ethamoxytriphetol (MER25) was the first. However, based on studies in rats and mice, initial hopes were that nonsteroidal anti-estrogens would be new “morning after pills.” However, the discovery that clomiphene and tamoxifen induced ovulation in subfertile women would produce only a niche market in the 1960s. The treatment of metastatic breast cancer was an obvious choice as endocrine ablative surgery, i.e., oophorectomy, adrenalectomy, or hypophysectomy, was standard of care. Over a decade, in the 1970s, numerous nonsteroidal anti-estrogens were tested, but only tamoxifen went forward for the treatment of all stages of breast cancer, ductal carcinoma in situ, and male breast cancer and the reduction of risk for breast cancer in high-risk pre- and postmenopausal women." @default.
- W2897563186 created "2018-10-26" @default.
- W2897563186 creator A5007718913 @default.
- W2897563186 creator A5049919852 @default.
- W2897563186 date "2018-10-17" @default.
- W2897563186 modified "2023-10-16" @default.
- W2897563186 title "The First Targeted Therapy to Treat Cancer: The Tamoxifen Tale" @default.
- W2897563186 cites W1500505511 @default.
- W2897563186 cites W1506399025 @default.
- W2897563186 cites W1559518404 @default.
- W2897563186 cites W1562190372 @default.
- W2897563186 cites W1961026612 @default.
- W2897563186 cites W1965965888 @default.
- W2897563186 cites W1966623655 @default.
- W2897563186 cites W1971628094 @default.
- W2897563186 cites W1980738888 @default.
- W2897563186 cites W1980894884 @default.
- W2897563186 cites W1982772639 @default.
- W2897563186 cites W1983360066 @default.
- W2897563186 cites W1983588233 @default.
- W2897563186 cites W1986555706 @default.
- W2897563186 cites W1987200013 @default.
- W2897563186 cites W1987673990 @default.
- W2897563186 cites W1992502560 @default.
- W2897563186 cites W1993193232 @default.
- W2897563186 cites W1993430370 @default.
- W2897563186 cites W1995360221 @default.
- W2897563186 cites W1998525632 @default.
- W2897563186 cites W2001652125 @default.
- W2897563186 cites W2001664183 @default.
- W2897563186 cites W2002000177 @default.
- W2897563186 cites W2002041504 @default.
- W2897563186 cites W2003010455 @default.
- W2897563186 cites W2004384839 @default.
- W2897563186 cites W2005815786 @default.
- W2897563186 cites W2007165008 @default.
- W2897563186 cites W2010440101 @default.
- W2897563186 cites W2013352145 @default.
- W2897563186 cites W2014987264 @default.
- W2897563186 cites W2015257205 @default.
- W2897563186 cites W2017681812 @default.
- W2897563186 cites W2026683867 @default.
- W2897563186 cites W2029777074 @default.
- W2897563186 cites W2031549494 @default.
- W2897563186 cites W2032654223 @default.
- W2897563186 cites W2033106148 @default.
- W2897563186 cites W2033453068 @default.
- W2897563186 cites W2035291486 @default.
- W2897563186 cites W2038114073 @default.
- W2897563186 cites W2039172078 @default.
- W2897563186 cites W2039628906 @default.
- W2897563186 cites W2040532631 @default.
- W2897563186 cites W2042162210 @default.
- W2897563186 cites W2045204082 @default.
- W2897563186 cites W2045816457 @default.
- W2897563186 cites W2046082688 @default.
- W2897563186 cites W2048013158 @default.
- W2897563186 cites W2048800387 @default.
- W2897563186 cites W2055936599 @default.
- W2897563186 cites W2058088062 @default.
- W2897563186 cites W2058088783 @default.
- W2897563186 cites W2059153388 @default.
- W2897563186 cites W2061352113 @default.
- W2897563186 cites W2061739720 @default.
- W2897563186 cites W2062798076 @default.
- W2897563186 cites W2064707298 @default.
- W2897563186 cites W2068419837 @default.
- W2897563186 cites W2068435339 @default.
- W2897563186 cites W2068921569 @default.
- W2897563186 cites W2071241613 @default.
- W2897563186 cites W2072270120 @default.
- W2897563186 cites W2074335085 @default.
- W2897563186 cites W2074769389 @default.
- W2897563186 cites W2075419022 @default.
- W2897563186 cites W2081631738 @default.
- W2897563186 cites W2081998608 @default.
- W2897563186 cites W2082963913 @default.
- W2897563186 cites W2083179705 @default.
- W2897563186 cites W2083589273 @default.
- W2897563186 cites W2085368051 @default.
- W2897563186 cites W2092626640 @default.
- W2897563186 cites W2101738855 @default.
- W2897563186 cites W2102087650 @default.
- W2897563186 cites W2110771245 @default.
- W2897563186 cites W2111650618 @default.
- W2897563186 cites W2112577860 @default.
- W2897563186 cites W2115020988 @default.
- W2897563186 cites W2115137592 @default.
- W2897563186 cites W2115991431 @default.
- W2897563186 cites W2118728607 @default.
- W2897563186 cites W2119041960 @default.
- W2897563186 cites W2119120445 @default.
- W2897563186 cites W2126078676 @default.
- W2897563186 cites W2133667885 @default.
- W2897563186 cites W2134627266 @default.
- W2897563186 cites W2136020634 @default.
- W2897563186 cites W2139726760 @default.
- W2897563186 cites W2161977537 @default.