FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897564188> ?p ?o ?g. }

• W2897564188 endingPage "2702" @default.
• W2897564188 startingPage "2702" @default.
• W2897564188 abstract "Sibirioside A and angoroside C are two important phenylpropanoid glycosides of the traditional Chinese medicine Scrophulariae Radix. High performance liquid chromatography, coupled with an ion trap time-of-flight multistage mass spectrometry equipped with electrospray ionization source (HPLC-ESI-IT-TOF-MSn), was applied to the profile and we identified the metabolites of sibirioside A and angoroside C in vivo in rats. A total of four metabolites of sibirioside A were identified: SM1, SM2 and SM3 which were known as new compounds. A total of 25 metabolites were detected for angoroside C: AM4, AM5, AM6, AM7, AM16, AM17, AM20, AM21, AM22, AM23 and AM25 which were identified to be new compounds. The main metabolic reactions were hydrolysis, reduction, hydroxylation, methylation, sulfation, and gluconylation. The prototype of sibirioside A was widely distributed in tissues found in the heart, liver, spleen, lung, kidney, stomach and small intestine of rats, and mainly distributed in the stomach, small intestine, kidney and liver. But for angoroside C, nothing was found in the viscera except the stomach and small intestine. The metabolites of sibirioside A were mainly eliminated from feces, while it was urine for the metabolites of angoroside C. Furthermore, 19 metabolites were likely to have bioactivities based on the ‘PharmMapper’ analysis, which roughly matched the known pharmacological activities of Scrophulariae Radix (SR) and the prototypes. One of the main pharmacological activities of SR in traditional Chinese medicine is anti-diabetes, and the predicted results showed that SM1, SM2, SM3, AM2, AM4, AM5, AM6, AM9, AM10, AM11, AM12, AM13, AM15, AM18, AM19, AM24, and AM25 might be used to cure diabetes. These findings provide a reference for studying the metabolism, distribution and pharmacological actions of phenylpropanoid glycosides in vivo." @default.
• W2897564188 created "2018-10-26" @default.
• W2897564188 creator A5032632492 @default.
• W2897564188 creator A5033764486 @default.
• W2897564188 creator A5036658104 @default.
• W2897564188 creator A5043565162 @default.
• W2897564188 creator A5066341237 @default.
• W2897564188 creator A5067565590 @default.
• W2897564188 date "2018-10-19" @default.
• W2897564188 modified "2023-09-26" @default.
• W2897564188 title "Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MSn" @default.
• W2897564188 cites W1970359828 @default.
• W2897564188 cites W1976196587 @default.
• W2897564188 cites W1983098607 @default.
• W2897564188 cites W2031358524 @default.
• W2897564188 cites W2031919829 @default.
• W2897564188 cites W2047956101 @default.
• W2897564188 cites W2049277503 @default.
• W2897564188 cites W2066351072 @default.
• W2897564188 cites W2086584196 @default.
• W2897564188 cites W2104916446 @default.
• W2897564188 cites W2111909972 @default.
• W2897564188 cites W2148088350 @default.
• W2897564188 cites W2150094438 @default.
• W2897564188 cites W2160293048 @default.
• W2897564188 cites W2168445982 @default.
• W2897564188 cites W2193969076 @default.
• W2897564188 cites W2258354873 @default.
• W2897564188 cites W2320193593 @default.
• W2897564188 cites W2377231104 @default.
• W2897564188 cites W2407564830 @default.
• W2897564188 cites W2409919687 @default.
• W2897564188 cites W257714394 @default.
• W2897564188 cites W2600084872 @default.
• W2897564188 cites W2611425558 @default.
• W2897564188 cites W2792013819 @default.
• W2897564188 doi "https://doi.org/10.3390/molecules23102702" @default.
• W2897564188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6222638" @default.
• W2897564188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347747" @default.
• W2897564188 hasPublicationYear "2018" @default.
• W2897564188 type Work @default.
• W2897564188 sameAs 2897564188 @default.
• W2897564188 citedByCount "5" @default.
• W2897564188 countsByYear W28975641882020 @default.
• W2897564188 countsByYear W28975641882021 @default.
• W2897564188 countsByYear W28975641882022 @default.
• W2897564188 countsByYear W28975641882023 @default.
• W2897564188 crossrefType "journal-article" @default.
• W2897564188 hasAuthorship W2897564188A5032632492 @default.
• W2897564188 hasAuthorship W2897564188A5033764486 @default.
• W2897564188 hasAuthorship W2897564188A5036658104 @default.
• W2897564188 hasAuthorship W2897564188A5043565162 @default.
• W2897564188 hasAuthorship W2897564188A5066341237 @default.
• W2897564188 hasAuthorship W2897564188A5067565590 @default.
• W2897564188 hasBestOaLocation W28975641881 @default.
• W2897564188 hasConcept C134018914 @default.
• W2897564188 hasConcept C150903083 @default.
• W2897564188 hasConcept C155138218 @default.
• W2897564188 hasConcept C162356407 @default.
• W2897564188 hasConcept C179998833 @default.
• W2897564188 hasConcept C181199279 @default.
• W2897564188 hasConcept C185592680 @default.
• W2897564188 hasConcept C192989942 @default.
• W2897564188 hasConcept C207001950 @default.
• W2897564188 hasConcept C2776918747 @default.
• W2897564188 hasConcept C2777477808 @default.
• W2897564188 hasConcept C2777882243 @default.
• W2897564188 hasConcept C2779091547 @default.
• W2897564188 hasConcept C2780026642 @default.
• W2897564188 hasConcept C2780091579 @default.
• W2897564188 hasConcept C2781109383 @default.
• W2897564188 hasConcept C31827203 @default.
• W2897564188 hasConcept C40684141 @default.
• W2897564188 hasConcept C43617362 @default.
• W2897564188 hasConcept C55493867 @default.
• W2897564188 hasConcept C59822182 @default.
• W2897564188 hasConcept C62231903 @default.
• W2897564188 hasConcept C86803240 @default.
• W2897564188 hasConceptScore W2897564188C134018914 @default.
• W2897564188 hasConceptScore W2897564188C150903083 @default.
• W2897564188 hasConceptScore W2897564188C155138218 @default.
• W2897564188 hasConceptScore W2897564188C162356407 @default.
• W2897564188 hasConceptScore W2897564188C179998833 @default.
• W2897564188 hasConceptScore W2897564188C181199279 @default.
• W2897564188 hasConceptScore W2897564188C185592680 @default.
• W2897564188 hasConceptScore W2897564188C192989942 @default.
• W2897564188 hasConceptScore W2897564188C207001950 @default.
• W2897564188 hasConceptScore W2897564188C2776918747 @default.
• W2897564188 hasConceptScore W2897564188C2777477808 @default.
• W2897564188 hasConceptScore W2897564188C2777882243 @default.
• W2897564188 hasConceptScore W2897564188C2779091547 @default.
• W2897564188 hasConceptScore W2897564188C2780026642 @default.
• W2897564188 hasConceptScore W2897564188C2780091579 @default.
• W2897564188 hasConceptScore W2897564188C2781109383 @default.
• W2897564188 hasConceptScore W2897564188C31827203 @default.
• W2897564188 hasConceptScore W2897564188C40684141 @default.
• W2897564188 hasConceptScore W2897564188C43617362 @default.
• W2897564188 hasConceptScore W2897564188C55493867 @default.

• next