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• W2897567577 abstract "<b><i>Objective:</i></b> Polycystic ovary syndrome (PCOS) is a serious endocrine disorder. In the present study, we investigated the therapeutic effects of erdosteine in letrozole-induced PCOS in rats. <b><i>Methods:</i></b> Thirty-two Wistar albino female rats were grouped as control group (C), PCOS group (PCOS), PCOS-metformin group (PCOS+MET), and PCOS-erdosteine group (PCOS+Erd). PCOS was induced by administering letrozole; such rats presented with sex hormone disorder, abnormal estrous cycles determined by daily vaginal smear, large cystic follicles, and increasing fasting insulin levels. After induction of PCOS, metformin (500 mg/kg/day) and erdosteine (100 mg/kg/day) were given orally to the treatment groups for 30 days. Serum concentrations of glucose, total cholesterol, low- and high-density lipoprotein, triglyceride, as well as the total oxidant and antioxidant status, oxidative stress index, circulating estrone (E1), estradiol (E2), testosterone, and androstenedione were evaluated. The ovaries were graded histologically. <b><i>Results:</i></b> Weights of ovarian tissues (<i>p</i> &#x3c; 0.05) and the number of atretic follicles (<i>p</i> &#x3c; 0.001) and cystic follicles (<i>p</i> &#x3c; 0.01) decreased in the PCOS+Erd group; the corpus luteum number was significantly higher in the PCOS+Erd group (<i>p</i> &#x3c; 0.01) as compared with the PCOS group. Lipid parameters (total-C, LDL-C, and TG), E1 (estrone), E1/E2 ratio, testosterone, and androstenedione significantly decreased, while HDL-C and E2 (estradiol) significantly increased in the PCOS+Erd group as compared with the PCOS group. Moreover glucose, insulin, and HOMA-IR were reduced with treatment of erdosteine (<i>p</i> &#x3e; 0.05, <i>p</i> &#x3c; 0.001, and <i>p</i> &#x3c; 0.001, respectively). <b><i>Conclusion:</i></b> It is suggested that erdosteine may be used in the treatment of PCOS as an alternative to metformin. It appears that our findings might be supported by clinical and molecular studies." @default.
• W2897567577 created "2018-10-26" @default.
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• W2897567577 date "2018-01-01" @default.
• W2897567577 modified "2023-10-12" @default.
• W2897567577 title "Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model" @default.
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• W2897567577 doi "https://doi.org/10.1159/000494300" @default.
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