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- W2897567760 abstract "Background Progesterone, a female sex hormone, is known to induce secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. It has been suggested that a causative factor in many cases of miscarriage may be inadequate secretion of progesterone. Therefore, clinicians use progestogens (drugs that interact with the progesterone receptors), beginning in the first trimester of pregnancy, in an attempt to prevent spontaneous miscarriage. This is an update of a review, last published in 2013. Objectives To assess the efficacy and safety of progestogens as a preventative therapy against recurrent miscarriage. Search methods For this update, we searched Cochrane Pregnancy and Childbirth’s Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) (6 July 2017) and reference lists from relevant articles, attempting to contact trial authors where necessary, and contacted experts in the field for unpublished works. Selection criteria Randomized or quasi‐randomized controlled trials comparing progestogens with placebo or no treatment given in an effort to prevent miscarriage. Data collection and analysis Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. Two reviewers assessed the quality of the evidence using the GRADE approach. Main results Twelve trials (1,856 women) met the inclusion criteria. Eight of the included trials compared treatment with placebo and the remaining four trials compared progestogen administration with no treatment. The trials were a mix of multicenter and single‐center trials, conducted in India, Jordan, UK and USA. In five trials women had had three or more consecutive miscarriages and in seven trials women had suffered two or more consecutive miscarriages. Routes, dosage and duration of progestogen treatment varied across the trials. The majority of trials were at low risk of bias for most domains. Ten trials (1684 women) contributed data to the analyses. The meta‐analysis of all women, suggests that there may be a reduction in the number of miscarriages for women given progestogen supplementation compared to placebo/controls (average risk ratio (RR) 0.73, 95% confidence interval (CI) 0.54 to 1.00, 10 trials, 1684 women, moderate‐quality evidence). A subgroup analysis comparing placebo‐controlled versus non‐placebo‐controlled trials, trials of women with three or more prior miscarriages compared to women with two or more miscarriages and different routes of administration showed no clear differences between subgroups for miscarriage. None of the trials reported on any secondary maternal outcomes, including severity of morning sickness, thromboembolic events, depression, admission to a special care unit, or subsequent fertility. There was probably a slight benefit for women receiving progestogen seen in the outcome of live birth rate (RR 1.07, 95% CI 1.00 to 1.13, 6 trials, 1411 women, moderate‐quality evidence). We are uncertain about the effect on the rate of preterm birth because the evidence is very low‐quality (RR 1.13, 95% CI 0.53 to 2.41, 4 trials, 256 women, very low‐quality evidence). No clear differences were seen for women receiving progestogen for the other secondary outcomes including neonatal death, fetal genital abnormalities or stillbirth. There may be little or no difference in the rate of low birthweight and trials did not report on the secondary child outcomes of teratogenic effects or admission to a special care unit. Authors' conclusions For women with unexplained recurrent miscarriages, supplementation with progestogen therapy may reduce the rate of miscarriage in subsequent pregnancies." @default.
- W2897567760 created "2018-10-26" @default.
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- W2897567760 date "2018-10-09" @default.
- W2897567760 modified "2023-09-29" @default.
- W2897567760 title "Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology" @default.
- W2897567760 cites W1481646084 @default.
- W2897567760 cites W1505001959 @default.
- W2897567760 cites W175055541 @default.
- W2897567760 cites W1798672062 @default.
- W2897567760 cites W1971572886 @default.
- W2897567760 cites W1974166621 @default.
- W2897567760 cites W1986163467 @default.
- W2897567760 cites W1988070368 @default.
- W2897567760 cites W1991318839 @default.
- W2897567760 cites W1996298196 @default.
- W2897567760 cites W2007493749 @default.
- W2897567760 cites W2009844234 @default.
- W2897567760 cites W2010255706 @default.
- W2897567760 cites W2011807431 @default.
- W2897567760 cites W2020655032 @default.
- W2897567760 cites W2021649985 @default.
- W2897567760 cites W2035682554 @default.
- W2897567760 cites W2043272598 @default.
- W2897567760 cites W2049103906 @default.
- W2897567760 cites W2062588802 @default.
- W2897567760 cites W2072937415 @default.
- W2897567760 cites W2074111314 @default.
- W2897567760 cites W2079859241 @default.
- W2897567760 cites W2087405204 @default.
- W2897567760 cites W2099108096 @default.
- W2897567760 cites W2099546038 @default.
- W2897567760 cites W2100645707 @default.
- W2897567760 cites W2101329303 @default.
- W2897567760 cites W2104409603 @default.
- W2897567760 cites W2106808598 @default.
- W2897567760 cites W2119795795 @default.
- W2897567760 cites W2125435699 @default.
- W2897567760 cites W2131330176 @default.
- W2897567760 cites W2141940030 @default.
- W2897567760 cites W2161690295 @default.
- W2897567760 cites W2190560068 @default.
- W2897567760 cites W2236902456 @default.
- W2897567760 cites W2252934623 @default.
- W2897567760 cites W2284838887 @default.
- W2897567760 cites W2336810381 @default.
- W2897567760 cites W2340017361 @default.
- W2897567760 cites W2359527355 @default.
- W2897567760 cites W2403936163 @default.
- W2897567760 cites W2405137614 @default.
- W2897567760 cites W2407929205 @default.
- W2897567760 cites W2410150256 @default.
- W2897567760 cites W2415055251 @default.
- W2897567760 cites W2416045204 @default.
- W2897567760 cites W2417254369 @default.
- W2897567760 cites W2423108954 @default.
- W2897567760 cites W2435722706 @default.
- W2897567760 cites W2465736884 @default.
- W2897567760 cites W2550177873 @default.
- W2897567760 cites W2582660209 @default.
- W2897567760 cites W2588975138 @default.
- W2897567760 cites W4210983736 @default.
- W2897567760 cites W4211196564 @default.
- W2897567760 cites W4211199323 @default.
- W2897567760 cites W4241301459 @default.
- W2897567760 cites W4246562399 @default.
- W2897567760 cites W4251288009 @default.
- W2897567760 cites W4252504017 @default.
- W2897567760 cites W4300769595 @default.
- W2897567760 cites W4379185945 @default.
- W2897567760 cites W4385796392 @default.
- W2897567760 cites W91761860 @default.
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- W2897567760 doi "https://doi.org/10.1002/14651858.cd003511.pub4" @default.
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