Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897568450> ?p ?o ?g. }
- W2897568450 endingPage "290" @default.
- W2897568450 startingPage "283" @default.
- W2897568450 abstract "The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their broad substrate scope and catalytic versatility, P450 enzymes are also attractive candidates for many industrial and biopharmaceutical applications. For particular uses, enzyme properties of P450s can be further optimized through directed evolution, rational, and semi-rational engineering approaches, all of which introduce mutations within the P450 structures. In this review, we describe the recent applications of these P450 engineering approaches and highlight the key regions and residues that have been identified using such approaches. These “hotspots” lie within critical functional areas of the P450 structure, including the active site, the substrate access channel, and the redox partner interaction interface." @default.
- W2897568450 created "2018-10-26" @default.
- W2897568450 creator A5009812789 @default.
- W2897568450 creator A5023643782 @default.
- W2897568450 date "2018-12-01" @default.
- W2897568450 modified "2023-09-24" @default.
- W2897568450 title "Rational and semi-rational engineering of cytochrome P450s for biotechnological applications" @default.
- W2897568450 cites W1498652161 @default.
- W2897568450 cites W1547482025 @default.
- W2897568450 cites W1559964610 @default.
- W2897568450 cites W1560469755 @default.
- W2897568450 cites W1907610088 @default.
- W2897568450 cites W1911058313 @default.
- W2897568450 cites W1963884707 @default.
- W2897568450 cites W1970896739 @default.
- W2897568450 cites W1974785399 @default.
- W2897568450 cites W1975206909 @default.
- W2897568450 cites W1975705716 @default.
- W2897568450 cites W1985152937 @default.
- W2897568450 cites W1995966723 @default.
- W2897568450 cites W1997754619 @default.
- W2897568450 cites W1998326599 @default.
- W2897568450 cites W2000051743 @default.
- W2897568450 cites W2000966246 @default.
- W2897568450 cites W2012801837 @default.
- W2897568450 cites W2016237430 @default.
- W2897568450 cites W2019278594 @default.
- W2897568450 cites W2021259617 @default.
- W2897568450 cites W2022319452 @default.
- W2897568450 cites W2025320442 @default.
- W2897568450 cites W2029160971 @default.
- W2897568450 cites W2034927638 @default.
- W2897568450 cites W2041121356 @default.
- W2897568450 cites W2041553704 @default.
- W2897568450 cites W2042040522 @default.
- W2897568450 cites W2042546121 @default.
- W2897568450 cites W2043184610 @default.
- W2897568450 cites W2047708413 @default.
- W2897568450 cites W2049222338 @default.
- W2897568450 cites W2055542085 @default.
- W2897568450 cites W2059850101 @default.
- W2897568450 cites W2063136279 @default.
- W2897568450 cites W2065544451 @default.
- W2897568450 cites W2068301791 @default.
- W2897568450 cites W2069014655 @default.
- W2897568450 cites W2072508442 @default.
- W2897568450 cites W2074907938 @default.
- W2897568450 cites W2077621515 @default.
- W2897568450 cites W2082384143 @default.
- W2897568450 cites W2084557052 @default.
- W2897568450 cites W2086118935 @default.
- W2897568450 cites W2101508521 @default.
- W2897568450 cites W2106257424 @default.
- W2897568450 cites W2108190540 @default.
- W2897568450 cites W2108738397 @default.
- W2897568450 cites W2121205779 @default.
- W2897568450 cites W2123868176 @default.
- W2897568450 cites W2124260805 @default.
- W2897568450 cites W2127091429 @default.
- W2897568450 cites W2127344845 @default.
- W2897568450 cites W2130674767 @default.
- W2897568450 cites W2137280662 @default.
- W2897568450 cites W2139185863 @default.
- W2897568450 cites W2140576468 @default.
- W2897568450 cites W2140615337 @default.
- W2897568450 cites W2144999739 @default.
- W2897568450 cites W2146630606 @default.
- W2897568450 cites W2153877336 @default.
- W2897568450 cites W2154598050 @default.
- W2897568450 cites W2161086998 @default.
- W2897568450 cites W2163086525 @default.
- W2897568450 cites W2311276428 @default.
- W2897568450 cites W2330591601 @default.
- W2897568450 cites W2416192302 @default.
- W2897568450 cites W2416691104 @default.
- W2897568450 cites W2468875970 @default.
- W2897568450 cites W2498151553 @default.
- W2897568450 cites W2509806303 @default.
- W2897568450 cites W2578368838 @default.
- W2897568450 cites W2586402208 @default.
- W2897568450 cites W2618541535 @default.
- W2897568450 cites W2618806840 @default.
- W2897568450 cites W2621393251 @default.
- W2897568450 cites W2735208100 @default.
- W2897568450 cites W2741590375 @default.
- W2897568450 cites W2742803394 @default.
- W2897568450 cites W2762791177 @default.
- W2897568450 cites W2765173544 @default.
- W2897568450 cites W2780676462 @default.
- W2897568450 cites W2790292679 @default.
- W2897568450 cites W2828833408 @default.
- W2897568450 cites W4244604248 @default.
- W2897568450 cites W4250196649 @default.
- W2897568450 cites W2011927858 @default.
- W2897568450 doi "https://doi.org/10.1016/j.synbio.2018.10.001" @default.
- W2897568450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6263019" @default.
- W2897568450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30533540" @default.
- W2897568450 hasPublicationYear "2018" @default.