FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897570538> ?p ?o ?g. }

• W2897570538 abstract "Abstract DNA methyltransferase inhibitor (DNMTi) treatments have been used for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), and have shown promising beneficial effects in some other types of cancers. Here, we demonstrate that the transcriptional repressor ZBTB38 is a critical regulator of the cellular response to DNMTi. Treatments with 5-azacytidine, or its derivatives decitabine and zebularine, lead to down-regulation of ZBTB38 protein expression in cancer cells, in parallel with cellular damage. The depletion of ZBTB38 by RNA interference enhances the toxicity of DNMTi in cell lines from leukemia and from various solid tumor types. Further we observed that inactivation of ZBTB38 causes the up-regulation of CDKN1C mRNA, a previously described indirect target of DNMTi. We show that CDKN1C is a key actor of DNMTi toxicity in cells lacking ZBTB38. Finally, in patients with MDS a high level of CDKN1C mRNA expression before treatment correlates with a better clinical response to a drug regimen combining 5-azacytidine and histone deacetylase inhibitors. Collectively, our results suggest that the ZBTB38 protein is a target of DNMTi and that its depletion potentiates the toxicity of DNMT inhibitors in cancer cells, providing new opportunities to enhance the response to DNMT inhibitor therapies in patients with MDS and other cancers." @default.
• W2897570538 created "2018-10-26" @default.
• W2897570538 creator A5003335031 @default.
• W2897570538 creator A5015606127 @default.
• W2897570538 creator A5032144125 @default.
• W2897570538 creator A5033436393 @default.
• W2897570538 creator A5049978831 @default.
• W2897570538 creator A5068688608 @default.
• W2897570538 creator A5075239166 @default.
• W2897570538 creator A5080590185 @default.
• W2897570538 creator A5090106152 @default.
• W2897570538 date "2018-10-11" @default.
• W2897570538 modified "2023-10-14" @default.
• W2897570538 title "Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation" @default.
• W2897570538 cites W1827923022 @default.
• W2897570538 cites W1905278501 @default.
• W2897570538 cites W1912679569 @default.
• W2897570538 cites W1953890763 @default.
• W2897570538 cites W1964809738 @default.
• W2897570538 cites W1966010937 @default.
• W2897570538 cites W1967731271 @default.
• W2897570538 cites W1970511165 @default.
• W2897570538 cites W1985704394 @default.
• W2897570538 cites W1991858306 @default.
• W2897570538 cites W1994041743 @default.
• W2897570538 cites W1995789257 @default.
• W2897570538 cites W1996588976 @default.
• W2897570538 cites W2011888402 @default.
• W2897570538 cites W2020730664 @default.
• W2897570538 cites W2025346428 @default.
• W2897570538 cites W2029816080 @default.
• W2897570538 cites W2034779436 @default.
• W2897570538 cites W2035462330 @default.
• W2897570538 cites W2043398720 @default.
• W2897570538 cites W2062135903 @default.
• W2897570538 cites W2074322136 @default.
• W2897570538 cites W2081895311 @default.
• W2897570538 cites W2082857671 @default.
• W2897570538 cites W2095066915 @default.
• W2897570538 cites W2106335654 @default.
• W2897570538 cites W2106833395 @default.
• W2897570538 cites W2110803599 @default.
• W2897570538 cites W2113299082 @default.
• W2897570538 cites W2122607246 @default.
• W2897570538 cites W2135094627 @default.
• W2897570538 cites W2141456042 @default.
• W2897570538 cites W2146315095 @default.
• W2897570538 cites W2146680808 @default.
• W2897570538 cites W2149785322 @default.
• W2897570538 cites W2168704508 @default.
• W2897570538 cites W2304098363 @default.
• W2897570538 cites W2317381314 @default.
• W2897570538 cites W2342532156 @default.
• W2897570538 cites W2374857763 @default.
• W2897570538 cites W2522597563 @default.
• W2897570538 cites W2525821325 @default.
• W2897570538 cites W2546980845 @default.
• W2897570538 cites W2547746944 @default.
• W2897570538 cites W2549790759 @default.
• W2897570538 cites W2554345186 @default.
• W2897570538 cites W2572628969 @default.
• W2897570538 cites W2572952103 @default.
• W2897570538 cites W2583644779 @default.
• W2897570538 cites W2739087647 @default.
• W2897570538 cites W2780087400 @default.
• W2897570538 cites W2791895112 @default.
• W2897570538 cites W2792453820 @default.
• W2897570538 doi "https://doi.org/10.1038/s41389-018-0092-0" @default.
• W2897570538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182000" @default.
• W2897570538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310057" @default.
• W2897570538 hasPublicationYear "2018" @default.
• W2897570538 type Work @default.
• W2897570538 sameAs 2897570538 @default.
• W2897570538 citedByCount "14" @default.
• W2897570538 countsByYear W28975705382018 @default.
• W2897570538 countsByYear W28975705382019 @default.
• W2897570538 countsByYear W28975705382020 @default.
• W2897570538 countsByYear W28975705382021 @default.
• W2897570538 countsByYear W28975705382022 @default.
• W2897570538 crossrefType "journal-article" @default.
• W2897570538 hasAuthorship W2897570538A5003335031 @default.
• W2897570538 hasAuthorship W2897570538A5015606127 @default.
• W2897570538 hasAuthorship W2897570538A5032144125 @default.
• W2897570538 hasAuthorship W2897570538A5033436393 @default.
• W2897570538 hasAuthorship W2897570538A5049978831 @default.
• W2897570538 hasAuthorship W2897570538A5068688608 @default.
• W2897570538 hasAuthorship W2897570538A5075239166 @default.
• W2897570538 hasAuthorship W2897570538A5080590185 @default.
• W2897570538 hasAuthorship W2897570538A5090106152 @default.
• W2897570538 hasBestOaLocation W28975705381 @default.
• W2897570538 hasConcept C104317684 @default.
• W2897570538 hasConcept C150194340 @default.
• W2897570538 hasConcept C158448853 @default.
• W2897570538 hasConcept C190727270 @default.
• W2897570538 hasConcept C2776202225 @default.
• W2897570538 hasConcept C2776239401 @default.
• W2897570538 hasConcept C2778305200 @default.
• W2897570538 hasConcept C2779277951 @default.
• W2897570538 hasConcept C2779979206 @default.
• W2897570538 hasConcept C2780235182 @default.

• next