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• W2897572384 abstract "Environmental estrogens are capable of interfering with the spermatogenesis and fertility of fish. However in natural waters, these chemicals are more likely to occur as a combination rather than a single stressor. Whether and how the mixture of xenoestrogens with environmental relevant concentrations may affect fish spermatogenesis remains largely unknown. In this study, male zebrafish adults were administered to 17alpha-ethinylestradiol (EE2) and a mixture of xenoestrogens (Mix (E2, EE2, DES, 4-t-OP, 4-NP and BPA)), with the estrogenic potency equivalent to EE2. After a 60-day exposures, elevated mRNA levels of vitellogenin 1 (vtg1) and estrogen receptor 1 (esr1) in the liver of fish in both treated groups were observed. Moreover, the plasma level of E2 declined significantly in the Mix group and the ratio of 11-KT/E2 was significantly elevated in both treated groups. Consistently, the mRNA level of P450 side-chain cleavage (scc) in the EE2 group and ovarian type aromatase (cyp19a1a) in the Mix group was significantly suppressed. In addition, decreased gonadosomatic index and sperm count in the fish of Mix group were present. Furthermore, increased number of the proliferating germ cells (such as spermatogonia and spermatocytes) was observed in the fish of both groups, suggesting a stimulated germ cell proliferation and meiosis. Accordingly, both exposures significantly up-regulated the mRNA levels of genes in mitosis (cyclinb1) and meiosis (cyp26a1 in EE2 group, aldh1a2, cyp26a1, sycp3 and spo11 in Mix). In addition, decreased number of spermatozoa and increased number of TUNEL-positive signals were present in the testis of fish in the Mix group, indicating an enhanced apoptosis. Further analyses demonstrated the significant elevated expressions of tnfrsf1a and the ratio of tnfrsf1a/tnfrsf1b in the Mix group, suggesting an elevated apoptosis in the testis of fish in the Mix group via extrinsic pathway. The present study greatly extends our understanding of the underlying mechanisms of the reproductive toxicity of xenoestrogens on fish." @default.
• W2897572384 created "2018-10-26" @default.
• W2897572384 creator A5029299515 @default.
• W2897572384 creator A5051159200 @default.
• W2897572384 creator A5064827993 @default.
• W2897572384 creator A5081657807 @default.
• W2897572384 date "2019-01-01" @default.
• W2897572384 modified "2023-10-16" @default.
• W2897572384 title "Long-term exposure of xenoestrogens with environmental relevant concentrations disrupted spermatogenesis of zebrafish through altering sex hormone balance, stimulating germ cell proliferation, meiosis and enhancing apoptosis" @default.
• W2897572384 cites W1481088207 @default.
• W2897572384 cites W1498045662 @default.
• W2897572384 cites W1607777232 @default.
• W2897572384 cites W1812111287 @default.
• W2897572384 cites W1898609403 @default.
• W2897572384 cites W1967971205 @default.
• W2897572384 cites W1970522623 @default.
• W2897572384 cites W1976883744 @default.
• W2897572384 cites W1977258127 @default.
• W2897572384 cites W1979603948 @default.
• W2897572384 cites W1981348969 @default.
• W2897572384 cites W1983570177 @default.
• W2897572384 cites W1986151197 @default.
• W2897572384 cites W1987393396 @default.
• W2897572384 cites W2002481914 @default.
• W2897572384 cites W2004464528 @default.
• W2897572384 cites W2004841060 @default.
• W2897572384 cites W2005195078 @default.
• W2897572384 cites W2010564153 @default.
• W2897572384 cites W2011748718 @default.
• W2897572384 cites W2013573413 @default.
• W2897572384 cites W2015168814 @default.
• W2897572384 cites W2015750766 @default.
• W2897572384 cites W2017150060 @default.
• W2897572384 cites W2023521447 @default.
• W2897572384 cites W2023666759 @default.
• W2897572384 cites W2024724149 @default.
• W2897572384 cites W2028079118 @default.
• W2897572384 cites W2034246488 @default.
• W2897572384 cites W2038894740 @default.
• W2897572384 cites W2043749350 @default.
• W2897572384 cites W2048122753 @default.
• W2897572384 cites W2048327581 @default.
• W2897572384 cites W2055386424 @default.
• W2897572384 cites W2056663411 @default.
• W2897572384 cites W2059174999 @default.
• W2897572384 cites W2059692457 @default.
• W2897572384 cites W2059706835 @default.
• W2897572384 cites W2059912186 @default.
• W2897572384 cites W2060158929 @default.
• W2897572384 cites W2069157996 @default.
• W2897572384 cites W2072747624 @default.
• W2897572384 cites W2074159402 @default.
• W2897572384 cites W2075553349 @default.
• W2897572384 cites W2082559531 @default.
• W2897572384 cites W2083095668 @default.
• W2897572384 cites W2090152026 @default.
• W2897572384 cites W2091955020 @default.
• W2897572384 cites W2095013915 @default.
• W2897572384 cites W2096047383 @default.
• W2897572384 cites W2098412103 @default.
• W2897572384 cites W2099814203 @default.
• W2897572384 cites W2107277218 @default.
• W2897572384 cites W2111480141 @default.
• W2897572384 cites W2118346170 @default.
• W2897572384 cites W2122097838 @default.
• W2897572384 cites W2126074172 @default.
• W2897572384 cites W2140462704 @default.
• W2897572384 cites W2143853738 @default.
• W2897572384 cites W2147294166 @default.
• W2897572384 cites W2150048195 @default.
• W2897572384 cites W2151727566 @default.
• W2897572384 cites W2159401430 @default.
• W2897572384 cites W2163791270 @default.
• W2897572384 cites W2166943250 @default.
• W2897572384 cites W2169412126 @default.
• W2897572384 cites W2226222348 @default.
• W2897572384 cites W2271700408 @default.
• W2897572384 cites W2279299740 @default.
• W2897572384 cites W2333259830 @default.
• W2897572384 cites W2342566904 @default.
• W2897572384 cites W2343449342 @default.
• W2897572384 cites W2410870033 @default.
• W2897572384 cites W2586174650 @default.
• W2897572384 cites W2757303858 @default.
• W2897572384 cites W2770160637 @default.
• W2897572384 cites W2779901387 @default.
• W2897572384 cites W2782833121 @default.
• W2897572384 cites W2784043777 @default.
• W2897572384 cites W4248443104 @default.
• W2897572384 doi "https://doi.org/10.1016/j.envpol.2018.10.079" @default.
• W2897572384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366296" @default.
• W2897572384 hasPublicationYear "2019" @default.
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