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- W2897573136 abstract "Abstract A method using planar chromatography (PC) was developed for determining lamotrigine (LTG; 3,5- diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) in human plasma and tablets. LTG was extracted with acetonitrile in the presence of sodium carbonate. 3,5-Diamino-6-(2-methoxyphenyl)-1,2,4-triazine was used as internal standard. The detection limit was 0.27 μg/mL plasma and the recovery from human plasma fortified with various concentrations of LTG was 91.3 ± 3.4%. Interference from other common antiepileptic agents was checked. Results obtained with the PC method were compared with those obtained by a method using liquid chromatography (LC) for analysis of plasma and with methods using LC and UV for assay of tablets." @default.
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- W2897573136 date "1996-11-01" @default.
- W2897573136 modified "2023-09-27" @default.
- W2897573136 title "Quantitative Analysis of Lamotrigine in Plasma and Tablets by Planar Chromatography and Comparison with Liquid Chromatography and UV Spectrophotometry" @default.
- W2897573136 doi "https://doi.org/10.1093/jaoac/79.6.1277" @default.
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