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- W2897574603 abstract "The prevalence of chronic pain increases with age. The pain occurrence in the elderly ranges from 25% to 80% in different countries. Ischemic heart disease is also prevailing in the aged people. Restored blood flow quickly rescues myocardium but also causes ischemia-reperfusion (IR) injury. Brief episodes of ischemia at a distant organ could reduce the myocardial reperfusion injury. This is called remote ischemic preconditioning (RIPC) cardioprotection. Several circulating factors and neurogenic signals contribute to the cardioprotection by RIPC. Preinfarction angina, a form of chest pain, is associated with significant cardioprotection in myocardial infarction patients. Activation of peripheral nociception also induces cardioprotection against IR injury via neurogenic pathway. It is possible that angina also induces nociceptive signal pathway to provide cardioprotection. It is unclear whether pre-existing chronic pain will also have a cardioprotection effect. We recently reported chronic neuropathic pain attenuates cardiac IR injury in mice. ERK activation in anterior nucleus of paraventricular thalamus (PVA) is required for this remote cardioprotection. Direct activation of PVA neurons also provides cardioprotection against cardiac IR injury. Chronic neuropathic pain-induced cardioprotection requires activation of parasympathetic nerves. This review summarizes the potential interaction of chronic pain and cardiac IR injury." @default.
- W2897574603 created "2018-10-26" @default.
- W2897574603 creator A5071538760 @default.
- W2897574603 creator A5078573194 @default.
- W2897574603 date "2018-01-01" @default.
- W2897574603 modified "2023-10-16" @default.
- W2897574603 title "Chronic Neuropathic Pain Protects the Heart from Ischemia-Reperfusion Injury" @default.
- W2897574603 cites W1743594125 @default.
- W2897574603 cites W1964849562 @default.
- W2897574603 cites W1966924587 @default.
- W2897574603 cites W1967861234 @default.
- W2897574603 cites W1971455395 @default.
- W2897574603 cites W1972351278 @default.
- W2897574603 cites W1976846134 @default.
- W2897574603 cites W1981013677 @default.
- W2897574603 cites W1981291046 @default.
- W2897574603 cites W1983257841 @default.
- W2897574603 cites W1987293815 @default.
- W2897574603 cites W1988592848 @default.
- W2897574603 cites W1993923536 @default.
- W2897574603 cites W1996030280 @default.
- W2897574603 cites W1999626957 @default.
- W2897574603 cites W2005306683 @default.
- W2897574603 cites W2005796050 @default.
- W2897574603 cites W2013679333 @default.
- W2897574603 cites W2015980149 @default.
- W2897574603 cites W2016474170 @default.
- W2897574603 cites W2020703194 @default.
- W2897574603 cites W2022473516 @default.
- W2897574603 cites W2026710628 @default.
- W2897574603 cites W2030584209 @default.
- W2897574603 cites W2032715486 @default.
- W2897574603 cites W2033207142 @default.
- W2897574603 cites W2045011381 @default.
- W2897574603 cites W2049938995 @default.
- W2897574603 cites W2050710630 @default.
- W2897574603 cites W2051395985 @default.
- W2897574603 cites W2054931962 @default.
- W2897574603 cites W2065950542 @default.
- W2897574603 cites W2066169163 @default.
- W2897574603 cites W2066231624 @default.
- W2897574603 cites W2080045599 @default.
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- W2897574603 cites W2085604801 @default.
- W2897574603 cites W2088600148 @default.
- W2897574603 cites W2088688806 @default.
- W2897574603 cites W2092852577 @default.
- W2897574603 cites W2093609306 @default.
- W2897574603 cites W2095334722 @default.
- W2897574603 cites W2098329072 @default.
- W2897574603 cites W2098712289 @default.
- W2897574603 cites W2103606060 @default.
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- W2897574603 cites W2167379989 @default.
- W2897574603 cites W2167541848 @default.
- W2897574603 cites W2178079095 @default.
- W2897574603 cites W2281735941 @default.
- W2897574603 cites W2318356582 @default.
- W2897574603 cites W2325867355 @default.
- W2897574603 cites W2332389703 @default.
- W2897574603 cites W2336628460 @default.
- W2897574603 cites W2343973495 @default.
- W2897574603 cites W2401998002 @default.
- W2897574603 cites W2411122968 @default.
- W2897574603 cites W2411728247 @default.
- W2897574603 cites W2464434570 @default.
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- W2897574603 doi "https://doi.org/10.1007/978-981-13-1756-9_9" @default.
- W2897574603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30306518" @default.
- W2897574603 hasPublicationYear "2018" @default.
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