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• W2897576072 abstract "Upregulated in lung cancer, miRNA-182 was found to be related to cancer proliferation and chemoresistance. However, there is no report on the role of miR-182 in radioresistance, which is a main obstacle of radiotherapy. In this study, we aim to depict the effect of miR-182 inhibition on cellular sensitivity to ionizing radiation. Our data confirm that miR-182 is upregulated in lung cancers and tissues and that miR-182 is responsive to irradiation. We also show that miR-182 knockdown suppresses cell proliferation and increases cell apoptosis after irradiation. DNA damage remains unrepaired in miR-182 knockdown cells, which results in cell cycle arrest. Finally, we find that FOXO3 is a direct target of miR-182 and that overexpression of FOXO3 enhances radiation resistance in miR-182 knockdown cells. In conclusion, our data suggest that miR-182 might account for radioresistance in lung cancer and that miR-182-FOXO3 provides a novel radiosensitizing target." @default.
• W2897576072 created "2018-10-26" @default.
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• W2897576072 date "2019-01-29" @default.
• W2897576072 modified "2023-09-28" @default.
• W2897576072 title "MiR-182 enhances radioresistance in non-small cell lung cancer cells by regulating FOXO3" @default.
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• W2897576072 doi "https://doi.org/10.1111/1440-1681.13041" @default.
• W2897576072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307642" @default.
• W2897576072 hasPublicationYear "2019" @default.
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