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- W2897577026 abstract "Alzheimer's disease (AD) strikes at the core of what makes us human: our capacity to think, to love, and to remember. Researchers have shown that AD starts years, if not decades before it is diagnosed. The sooner the disease can be diagnosed, the better treatment options can be provided Exhaled breath gas analysis offers an inexpensive, non-invasive and immediate method for detecting a large number of diseases, including AD. We developed an array of sensors to sense butylated hydroxytoluene, pivalic acid, and nonane, which are of the chemicals found in the breath print of AD patients. A three-layer sensor was formed through deposition of a thin layer of graphene onto a glassy carbon substrate. Selective binding of the analyte was facilitated by electrochemically-initiated polymerization of a solution containing the desired target molecule. Subsequent polymerization and removal of the analyte yielded a layer of polypyrrole, a conductive polymer, on top of the sensor containing molecularly imprinted cavities selective for the target molecule. So the chemical sensor imparts to the ultra high sensitivity of graphene and super selectivity of the molecular imprinting technique. Prussian blue was added to graphene before polymerization; mainly for enhancing the electrochemical properties. The sensors were tested over 0.5-80 parts per billion (ppb) level of concentration while the sensor resistance was monitored. Exposing them to water vapor and pure nitrogen tested stability of the sensors. The selectivity of the sensors was also verified by observing no change in electrical conductivity while they were exposed to similar chemicals. An array of three electrochemical gas sensors were fabricated and tested towards the chemicals found in the exhaled breath of AD patients. Each sensor is sensitive up to sub ppb level and only sense a specific chemical. This array can be used to detect specific chemicals in the exhaled breath of patients." @default.
- W2897577026 created "2018-10-26" @default.
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- W2897577026 date "2018-07-01" @default.
- W2897577026 modified "2023-10-16" @default.
- W2897577026 title "P4‐269: A MOLECULARLY IMPRINTED ELECTROCHEMICAL GAS SENSOR TO SENSE CHEMICALS IN AIR: A PATHWAY TO DIAGNOSIS OF ALZHEIMER'S DISEASE FROM EXHALED BREATH" @default.
- W2897577026 doi "https://doi.org/10.1016/j.jalz.2018.07.091" @default.
- W2897577026 hasPublicationYear "2018" @default.
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