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- W2897579654 abstract "ABSTRACT Although well known for its role in apoptosis, the executioner caspase DrICE has a non-apoptotic function that is required for elongation of the epithelial tubes of the Drosophila tracheal system. Here, we show that DrICE acts downstream of the Hippo Network to regulate endocytic trafficking of at least four cell polarity, cell junction and apical extracellular matrix proteins involved in tracheal tube size control: Crumbs, Uninflatable, Kune-Kune and Serpentine. We further show that tracheal cells are competent to undergo apoptosis, even though developmentally-regulated DrICE function rarely kills tracheal cells. Our results reveal a novel developmental role for caspases, a previously unidentified pool of DrICE that colocalizes with Clathrin, and a mechanism by which the Hippo Network controls endocytic trafficking. Given published reports of in vitro regulation of endocytosis by mammalian caspases during apoptosis, we propose that caspase-mediated regulation of endocytic trafficking is an evolutionarily conserved function of caspases that can be deployed during morphogenesis." @default.
- W2897579654 created "2018-10-26" @default.
- W2897579654 creator A5054417493 @default.
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- W2897579654 date "2018-10-21" @default.
- W2897579654 modified "2023-09-25" @default.
- W2897579654 title "The Caspase-3 homolog DrICE regulates endocytic trafficking during Drosophila tracheal morphogenesis" @default.
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- W2897579654 doi "https://doi.org/10.1101/448944" @default.
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