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- W2897580574 abstract "Abstract Introduction Apolipoprotein E ( APOE ) is a susceptibility gene for late‐onset Alzheimer's disease neuropathology; less is known about the relationship between APOE and cerebrovascular disease (CVD) neuropathology. Methods We investigated associations of APOE status with arteriolosclerosis, macroinfarcts and microinfarcts, and atherosclerosis in 1383 adults (65.9–108.2 years at death) with and without dementia. Excluding ε2/ε4 carriers, multivariable regressions for each CVD‐related neuropathology compared ε4 and ε2 carriers to ε3/ε3 carriers adjusting for confounders including age and Alzheimer's neuropathology. Results Three hundred forty‐two individuals (24.7%; ∼87.7 years at death; 39.9% nondemented) were ε3/ε4 or ε4/ε4, and 180 (13.0%; ∼89.9 years at death; 66.6% nondemented) were ε2/ε3 or ε2/ε2. ε4 carriers had higher odds of macroinfarcts (odds ratio = 1.41, 95% confidence interval: 1.02–1.94, P = .03), whereas ε2 carriers had higher odds of moderate‐to‐severe arteriolosclerosis (odds ratio = 1.68, 95% confidence interval: 1.15–2.45, P = .006) compared to ε3/ε3 carriers. Age‐stratified analyses suggested that these relationships were driven by ε4 carriers <90 years at death and ε2 carriers ≥90 years at death, respectively. Discussion APOE differentially affects type and timing of CVD‐related neuropathology." @default.
- W2897580574 created "2018-10-26" @default.
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- W2897580574 date "2018-10-12" @default.
- W2897580574 modified "2023-10-16" @default.
- W2897580574 title "<i>APOE</i> genotypes as a risk factor for age‐dependent accumulation of cerebrovascular disease in older adults" @default.
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- W2897580574 doi "https://doi.org/10.1016/j.jalz.2018.08.007" @default.
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