FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897591802> ?p ?o ?g. }

• W2897591802 endingPage "1901" @default.
• W2897591802 startingPage "1895" @default.
• W2897591802 abstract "Background Ticagrelor is an anti-platelet agent that is indicated for prevention of thrombosis after acute coronary syndrome or intra-coronary artery stent implantation, but it increases the risk of bleeding. Platelet transfusion has the potential to treat or prevent bleeding in patients taking ticagrelor, but the optimal quantity of platelets and timing of administration have not been fully defined. Methods and Results Ten healthy subjects took ticagrelor in combination with acetylsalicylic acid for 5 days, and had blood collected prior to treatment and at 2, 10, 24, 48, 72 and 96 hours after the last doses. The potential of platelet transfusion to prevent or reverse bleeding was evaluated by mixing subject and donor platelet-rich plasma in vitro in nine different proportions, and measuring adenosine diphosphate-mediated aggregation by light transmission aggregometry. Spontaneous offset of the anti-aggregant effect of ticagrelor occurred gradually and was complete at 72 hours after the last dose. The addition of donor platelets enhanced the recovery. The addition of the equivalent of six apheresis platelet units produced a 50% relative reversal at 10 hours, and > 90% reversal at 24 hours. Conclusion Donor platelets enhance reversal of the anti-aggregant effect of ticagrelor in vitro. Donor platelets given in clinically relevant amounts partially reversed ticagrelor at 10 hours after the last dose, and almost fully reversed ticagrelor at 24 hours. The results inform on the potential to reverse ticagrelor in patients who develop bleeding or require emergency surgery." @default.
• W2897591802 created "2018-10-26" @default.
• W2897591802 creator A5000623149 @default.
• W2897591802 creator A5000914852 @default.
• W2897591802 creator A5039531642 @default.
• W2897591802 creator A5055785288 @default.
• W2897591802 creator A5058706226 @default.
• W2897591802 creator A5061132830 @default.
• W2897591802 creator A5066523434 @default.
• W2897591802 creator A5078620574 @default.
• W2897591802 creator A5087630518 @default.
• W2897591802 date "2018-10-17" @default.
• W2897591802 modified "2023-09-26" @default.
• W2897591802 title "In Vitro Reversal of the Anti-Aggregant Effect of Ticagrelor Using Untreated Platelets" @default.
• W2897591802 cites W1566712571 @default.
• W2897591802 cites W175512219 @default.
• W2897591802 cites W1877581810 @default.
• W2897591802 cites W1976064940 @default.
• W2897591802 cites W1982513890 @default.
• W2897591802 cites W1982519656 @default.
• W2897591802 cites W1996664577 @default.
• W2897591802 cites W2003593234 @default.
• W2897591802 cites W2024656127 @default.
• W2897591802 cites W2063213732 @default.
• W2897591802 cites W2099539623 @default.
• W2897591802 cites W2099580327 @default.
• W2897591802 cites W2105225326 @default.
• W2897591802 cites W2129221838 @default.
• W2897591802 cites W2130667353 @default.
• W2897591802 cites W2131181128 @default.
• W2897591802 cites W2140501627 @default.
• W2897591802 cites W2153631612 @default.
• W2897591802 cites W2161055506 @default.
• W2897591802 cites W2318219273 @default.
• W2897591802 cites W2330509220 @default.
• W2897591802 cites W2359884680 @default.
• W2897591802 cites W2410076995 @default.
• W2897591802 cites W2477913293 @default.
• W2897591802 cites W2522187540 @default.
• W2897591802 cites W2563403859 @default.
• W2897591802 cites W2597486205 @default.
• W2897591802 cites W2607768916 @default.
• W2897591802 cites W2741901982 @default.
• W2897591802 doi "https://doi.org/10.1055/s-0038-1673381" @default.
• W2897591802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332695" @default.
• W2897591802 hasPublicationYear "2018" @default.
• W2897591802 type Work @default.
• W2897591802 sameAs 2897591802 @default.
• W2897591802 citedByCount "8" @default.
• W2897591802 countsByYear W28975918022019 @default.
• W2897591802 countsByYear W28975918022020 @default.
• W2897591802 crossrefType "journal-article" @default.
• W2897591802 hasAuthorship W2897591802A5000623149 @default.
• W2897591802 hasAuthorship W2897591802A5000914852 @default.
• W2897591802 hasAuthorship W2897591802A5039531642 @default.
• W2897591802 hasAuthorship W2897591802A5055785288 @default.
• W2897591802 hasAuthorship W2897591802A5058706226 @default.
• W2897591802 hasAuthorship W2897591802A5061132830 @default.
• W2897591802 hasAuthorship W2897591802A5066523434 @default.
• W2897591802 hasAuthorship W2897591802A5078620574 @default.
• W2897591802 hasAuthorship W2897591802A5087630518 @default.
• W2897591802 hasConcept C126322002 @default.
• W2897591802 hasConcept C164705383 @default.
• W2897591802 hasConcept C2776689292 @default.
• W2897591802 hasConcept C2777628954 @default.
• W2897591802 hasConcept C2777698277 @default.
• W2897591802 hasConcept C2777849778 @default.
• W2897591802 hasConcept C2780890252 @default.
• W2897591802 hasConcept C42219234 @default.
• W2897591802 hasConcept C500558357 @default.
• W2897591802 hasConcept C71924100 @default.
• W2897591802 hasConcept C89560881 @default.
• W2897591802 hasConcept C98274493 @default.
• W2897591802 hasConceptScore W2897591802C126322002 @default.
• W2897591802 hasConceptScore W2897591802C164705383 @default.
• W2897591802 hasConceptScore W2897591802C2776689292 @default.
• W2897591802 hasConceptScore W2897591802C2777628954 @default.
• W2897591802 hasConceptScore W2897591802C2777698277 @default.
• W2897591802 hasConceptScore W2897591802C2777849778 @default.
• W2897591802 hasConceptScore W2897591802C2780890252 @default.
• W2897591802 hasConceptScore W2897591802C42219234 @default.
• W2897591802 hasConceptScore W2897591802C500558357 @default.
• W2897591802 hasConceptScore W2897591802C71924100 @default.
• W2897591802 hasConceptScore W2897591802C89560881 @default.
• W2897591802 hasConceptScore W2897591802C98274493 @default.
• W2897591802 hasIssue "11" @default.
• W2897591802 hasLocation W28975918021 @default.
• W2897591802 hasLocation W28975918022 @default.
• W2897591802 hasOpenAccess W2897591802 @default.
• W2897591802 hasPrimaryLocation W28975918021 @default.
• W2897591802 hasRelatedWork W1982513890 @default.
• W2897591802 hasRelatedWork W2130667353 @default.
• W2897591802 hasRelatedWork W2134849884 @default.
• W2897591802 hasRelatedWork W2538235438 @default.
• W2897591802 hasRelatedWork W2759749682 @default.
• W2897591802 hasRelatedWork W2981214103 @default.
• W2897591802 hasRelatedWork W3119665449 @default.
• W2897591802 hasRelatedWork W3134665543 @default.

• next