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- W2897592735 abstract "To evaluate the value of adding fetal growth velocity parameters to maternal biochemical biomarkers for the detection of SGA neonates. A retrospective cohort study of 1094 singleton pregnancies, in the Maastricht University Medical Centre (MUMC) between 2011 and 2016. All women had ultrasound data of fetal growth from two periods: 18-22 and 30-34 weeks. The PAPP-A, β-hCG, PlGF and sFlt-1 values were measured at 11-13 weeks. Differences in maternal biochemical biomarkers and fetal growth velocities (mm/week) of the abdominal circumference (AC), biparietal diameter (BPD), head circumference (HC) and femur length (FL) were compared between the AGA (birth weight percentiles 10-90) and SGA (birth weight percentiles <10), using one-way ANOVA and post-hoc. Detection of SGA was calculated using ROC-curve and chi-square test. Compared to AGA (n=1049) as reference group, SGA (n=45) had significant lower growth velocities ACv (mean±SD) (10.08±0.98 vs 11.26±1.00, p<.0001), BPDv (2.78±0.29 vs 3.08±0.27, p<.0001), HCv (9.98±0.83 vs 10.67±0.82, p<.0001) and FLv (2.34±0.252 vs 2.52±0.20, p<.0001). SGA compared with AGA had lower PAPP-a MoM (0.87±0.48 vs 1.13±0.70, p=0.015), higher sFlt-1 (1283.96±699.36 vs 1088.21±480.80, p=0.048), and a higher sFlt-1/PlGF ratio (50.16±41.56 vs 35.67±19.68, p=0.002). Combining all maternal biomarkers resulted in an AUC of 0.762 (0.655-0.869), with a sensitivity 84.4% (95%CI 69.9-93.0%) and negative predictive value (NPV) 93.8% (95%CI, 87.1-97.2%) for the prediction of SGA. However, addition of fetal growth velocities to the maternal biomarkers, improves the prediction of SGA with an AUC of 0.823 (0.741-0.906) sensitivity 92.3% (95%CI 79.4-97.7%); specificity 50.0% (95%CI 43.7-56.3%); and NPV 97.3% (95%CI 92.3-99.2%). Detection of small-for-gestational-neonates can be improved using the combination of fetal growth velocity parameters and maternal biochemical markers. A larger prospective study including serial maternal biochemical markers is needed." @default.
- W2897592735 created "2018-10-26" @default.
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- W2897592735 date "2018-10-01" @default.
- W2897592735 modified "2023-09-27" @default.
- W2897592735 title "OC17.04: Adding fetal growth velocity parameters to maternal biochemical biomarkers improves the detection of small-for-gestational-age neonates" @default.
- W2897592735 doi "https://doi.org/10.1002/uog.19321" @default.
- W2897592735 hasPublicationYear "2018" @default.
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