FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897593929> ?p ?o ?g. }

• W2897593929 abstract "Given the emerging role of the peripheral immune system in the pathogenesis of Alzheimer's Disease (AD), we pursued a large-scale study describing AD related changes of RNA editing in blood. RNA editing, the post-transcriptional modification of individual bases, contributes to various biological processes including neuronal development and immune regulation. Historically, genetic studies of AD have focused primarily on Non-Hispanic Whites (NHW), but here we broaden our functional genomics efforts to include African American (AA) individuals in order to identify ethnicity-specific editing signatures in diverse AD populations. Our goal was to test whether RNA editing in blood reflects the immune regulatory changes that occur in AD. Whole transcriptome RNA sequencing was performed on peripheral blood specimens from 216 AD cases (105 AA, 111 NHW) and 212 matched controls (105 AA, 107 NHW). REDItools software was used to identify candidate editing events, and the output was filtered for quality. Differentially edited genes were analyzed against the set of genes that are expressed in blood for Gene Ontology term enrichment. Differentially edited sites affecting miRNA binding sites were identified using TargetScan. Editing events were detected at a total of 44985 positions. 449 positions in 254 genes were differentially edited in AA, and 723 positions in 351 genes were differentially edited in NHW. In both AA and NHW, genes with differential editing were enriched for biological processes related to immune regulation (p = 0.0000010), inflammation (p = 0.0000019), and endocytosis (p = 0.0010). Nearly half of all differentially edited genes in AA and NHW were associated with either immune system process or vesicle-mediated transport terms. Regulation of amyloid precursor protein catabolism was enriched in NHW. Differentially edited sites affected miRNA binding sites in multiple genes including PAFAH1B2 and HNRNPA1, which have previously been linked to AD-phenotypes in molecular studies." @default.
• W2897593929 created "2018-10-26" @default.
• W2897593929 creator A5016048222 @default.
• W2897593929 creator A5020266650 @default.
• W2897593929 creator A5020503630 @default.
• W2897593929 creator A5020855307 @default.
• W2897593929 creator A5032798711 @default.
• W2897593929 creator A5032846688 @default.
• W2897593929 creator A5039221620 @default.
• W2897593929 creator A5039717261 @default.
• W2897593929 creator A5040175506 @default.
• W2897593929 creator A5040949007 @default.
• W2897593929 creator A5066140517 @default.
• W2897593929 creator A5069324665 @default.
• W2897593929 creator A5083429290 @default.
• W2897593929 creator A5089104364 @default.
• W2897593929 creator A5090171621 @default.
• W2897593929 date "2018-07-01" @default.
• W2897593929 modified "2023-10-16" @default.
• W2897593929 title "O2‐01‐05: MULTI‐ETHNIC ALZHEIMER'S DISEASE RELATED CHANGES OF RNA EDITING AFFECT IMMUNE REGULATION, ENDOCYTOSIS, AND AMYLOID PRECURSOR PROTEIN CATABOLISM" @default.
• W2897593929 doi "https://doi.org/10.1016/j.jalz.2018.06.2643" @default.
• W2897593929 hasPublicationYear "2018" @default.
• W2897593929 type Work @default.
• W2897593929 sameAs 2897593929 @default.
• W2897593929 citedByCount "0" @default.
• W2897593929 crossrefType "journal-article" @default.
• W2897593929 hasAuthorship W2897593929A5016048222 @default.
• W2897593929 hasAuthorship W2897593929A5020266650 @default.
• W2897593929 hasAuthorship W2897593929A5020503630 @default.
• W2897593929 hasAuthorship W2897593929A5020855307 @default.
• W2897593929 hasAuthorship W2897593929A5032798711 @default.
• W2897593929 hasAuthorship W2897593929A5032846688 @default.
• W2897593929 hasAuthorship W2897593929A5039221620 @default.
• W2897593929 hasAuthorship W2897593929A5039717261 @default.
• W2897593929 hasAuthorship W2897593929A5040175506 @default.
• W2897593929 hasAuthorship W2897593929A5040949007 @default.
• W2897593929 hasAuthorship W2897593929A5066140517 @default.
• W2897593929 hasAuthorship W2897593929A5069324665 @default.
• W2897593929 hasAuthorship W2897593929A5083429290 @default.
• W2897593929 hasAuthorship W2897593929A5089104364 @default.
• W2897593929 hasAuthorship W2897593929A5090171621 @default.
• W2897593929 hasConcept C104317684 @default.
• W2897593929 hasConcept C150194340 @default.
• W2897593929 hasConcept C162317418 @default.
• W2897593929 hasConcept C21786251 @default.
• W2897593929 hasConcept C54355233 @default.
• W2897593929 hasConcept C67705224 @default.
• W2897593929 hasConcept C86803240 @default.
• W2897593929 hasConcept C8891405 @default.
• W2897593929 hasConceptScore W2897593929C104317684 @default.
• W2897593929 hasConceptScore W2897593929C150194340 @default.
• W2897593929 hasConceptScore W2897593929C162317418 @default.
• W2897593929 hasConceptScore W2897593929C21786251 @default.
• W2897593929 hasConceptScore W2897593929C54355233 @default.
• W2897593929 hasConceptScore W2897593929C67705224 @default.
• W2897593929 hasConceptScore W2897593929C86803240 @default.
• W2897593929 hasConceptScore W2897593929C8891405 @default.
• W2897593929 hasIssue "7S_Part_11" @default.
• W2897593929 hasLocation W28975939291 @default.
• W2897593929 hasOpenAccess W2897593929 @default.
• W2897593929 hasPrimaryLocation W28975939291 @default.
• W2897593929 hasRelatedWork W1971124177 @default.
• W2897593929 hasRelatedWork W2009966535 @default.
• W2897593929 hasRelatedWork W2131160279 @default.
• W2897593929 hasRelatedWork W2513916811 @default.
• W2897593929 hasRelatedWork W2810320185 @default.
• W2897593929 hasRelatedWork W3089353767 @default.
• W2897593929 hasRelatedWork W3097825150 @default.
• W2897593929 hasRelatedWork W3146618441 @default.
• W2897593929 hasRelatedWork W4213265720 @default.
• W2897593929 hasRelatedWork W4247273247 @default.
• W2897593929 hasVolume "14" @default.
• W2897593929 isParatext "false" @default.
• W2897593929 isRetracted "false" @default.
• W2897593929 magId "2897593929" @default.
• W2897593929 workType "article" @default.