FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897593985> ?p ?o ?g. }

• W2897593985 endingPage "179" @default.
• W2897593985 startingPage "170" @default.
• W2897593985 abstract "Taxanes are chemotherapeutic agents used in the treatment of solid tumors, particularly of breast, ovarian, and lung origin. However, patients show divergent therapy responses, and the molecular determinants of taxane sensitivity have remained elusive. Especially the signaling pathways that promote death of the taxane-treated cells are poorly characterized. Here we describe a novel part of a signaling route in which c-Myc enhances paclitaxel sensitivity through upregulation of miR-203b-3p and miR-203a-3p; two clustered antiapoptosis protein Bcl-xL controlling microRNAs. In vitro, the miR-203b-3p decreases the expression of Bcl-xL by direct targeting of the gene's mRNA 3’UTR. Notably, overexpression of the miR-203b-3p changed the fate of paclitaxel-treated breast and ovarian cancer cells from mitotic slippage to cell death. In breast tumors, high expression of the miR-203b-3p and MYC was associated with better therapy response and patient survival. Interestingly, in the breast tumors, MYC expression correlated negatively with BCL2L1 expression but positively with miR-203b-3p and miR-203a-3p. Finally, silencing of MYC suppressed the transcription of both miRNAs in breast tumor cells. Pending further validation, these results may assist in patient stratification for taxane therapy." @default.
• W2897593985 created "2018-10-26" @default.
• W2897593985 creator A5004840200 @default.
• W2897593985 creator A5013386835 @default.
• W2897593985 creator A5021408421 @default.
• W2897593985 creator A5035837487 @default.
• W2897593985 creator A5051474044 @default.
• W2897593985 creator A5071621068 @default.
• W2897593985 creator A5086211661 @default.
• W2897593985 date "2019-01-01" @default.
• W2897593985 modified "2023-10-18" @default.
• W2897593985 title "MYC-Induced miR-203b-3p and miR-203a-3p Control Bcl-xL Expression and Paclitaxel Sensitivity in Tumor Cells" @default.
• W2897593985 cites W1616592835 @default.
• W2897593985 cites W1808356505 @default.
• W2897593985 cites W1956409007 @default.
• W2897593985 cites W1971579914 @default.
• W2897593985 cites W1976874039 @default.
• W2897593985 cites W1977258127 @default.
• W2897593985 cites W2010461414 @default.
• W2897593985 cites W2014460958 @default.
• W2897593985 cites W2018361038 @default.
• W2897593985 cites W2029606078 @default.
• W2897593985 cites W2041724957 @default.
• W2897593985 cites W2048519468 @default.
• W2897593985 cites W2048938594 @default.
• W2897593985 cites W2071359790 @default.
• W2897593985 cites W2096283457 @default.
• W2897593985 cites W2098842169 @default.
• W2897593985 cites W2103450589 @default.
• W2897593985 cites W2105613536 @default.
• W2897593985 cites W2120865735 @default.
• W2897593985 cites W2124544785 @default.
• W2897593985 cites W2125554513 @default.
• W2897593985 cites W2126393916 @default.
• W2897593985 cites W2127925738 @default.
• W2897593985 cites W2129022059 @default.
• W2897593985 cites W2129949847 @default.
• W2897593985 cites W2129989599 @default.
• W2897593985 cites W2130842899 @default.
• W2897593985 cites W2130979840 @default.
• W2897593985 cites W2131132473 @default.
• W2897593985 cites W2132387160 @default.
• W2897593985 cites W2136370295 @default.
• W2897593985 cites W2147807172 @default.
• W2897593985 cites W2154603906 @default.
• W2897593985 cites W2154747925 @default.
• W2897593985 cites W2162602733 @default.
• W2897593985 cites W2162643935 @default.
• W2897593985 cites W2179438025 @default.
• W2897593985 cites W2259938310 @default.
• W2897593985 cites W2263311874 @default.
• W2897593985 cites W2275472821 @default.
• W2897593985 cites W2302397808 @default.
• W2897593985 cites W2498869634 @default.
• W2897593985 cites W2554598612 @default.
• W2897593985 cites W2608451332 @default.
• W2897593985 doi "https://doi.org/10.1016/j.tranon.2018.10.001" @default.
• W2897593985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199766" @default.
• W2897593985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30359947" @default.
• W2897593985 hasPublicationYear "2019" @default.
• W2897593985 type Work @default.
• W2897593985 sameAs 2897593985 @default.
• W2897593985 citedByCount "22" @default.
• W2897593985 countsByYear W28975939852019 @default.
• W2897593985 countsByYear W28975939852020 @default.
• W2897593985 countsByYear W28975939852021 @default.
• W2897593985 countsByYear W28975939852022 @default.
• W2897593985 countsByYear W28975939852023 @default.
• W2897593985 crossrefType "journal-article" @default.
• W2897593985 hasAuthorship W2897593985A5004840200 @default.
• W2897593985 hasAuthorship W2897593985A5013386835 @default.
• W2897593985 hasAuthorship W2897593985A5021408421 @default.
• W2897593985 hasAuthorship W2897593985A5035837487 @default.
• W2897593985 hasAuthorship W2897593985A5051474044 @default.
• W2897593985 hasAuthorship W2897593985A5071621068 @default.
• W2897593985 hasAuthorship W2897593985A5086211661 @default.
• W2897593985 hasBestOaLocation W28975939851 @default.
• W2897593985 hasConcept C104317684 @default.
• W2897593985 hasConcept C119056186 @default.
• W2897593985 hasConcept C121608353 @default.
• W2897593985 hasConcept C126322002 @default.
• W2897593985 hasConcept C127561419 @default.
• W2897593985 hasConcept C145059251 @default.
• W2897593985 hasConcept C2777292972 @default.
• W2897593985 hasConcept C2777511904 @default.
• W2897593985 hasConcept C502942594 @default.
• W2897593985 hasConcept C530470458 @default.
• W2897593985 hasConcept C55493867 @default.
• W2897593985 hasConcept C71924100 @default.
• W2897593985 hasConcept C86803240 @default.
• W2897593985 hasConceptScore W2897593985C104317684 @default.
• W2897593985 hasConceptScore W2897593985C119056186 @default.
• W2897593985 hasConceptScore W2897593985C121608353 @default.
• W2897593985 hasConceptScore W2897593985C126322002 @default.
• W2897593985 hasConceptScore W2897593985C127561419 @default.
• W2897593985 hasConceptScore W2897593985C145059251 @default.
• W2897593985 hasConceptScore W2897593985C2777292972 @default.
• W2897593985 hasConceptScore W2897593985C2777511904 @default.

• next