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- W2897594540 abstract "In a recent genome-wide association study (GWAS) of 59 cerebrospinal fluid proteins with a connection to the Alzheimer's disease (AD) the nonsynonymous mutations CCRL2-V180M (rs6441977) showed significant association with lower levels of the C-C chemokine ligand motif 4 (CCL4). In the same study and CCBP2-V41A (rs2228467) showed a correlation with high levels of C-C chemokine ligand motif 2 (CCL2) It is known that high level of CCL2 and CCL4 are associated with risk development of the disease. In this study, we will genotype rs6441977 and rs2228467 subjects from the Cache County Study on Memory in Aging to test for association with AD status, rate of cognitive decline, and levels of ten inflammatory cytokines. Genotyping will be conducted in 500 cases and 3800 controls using a TaqMan assay. We will then use logistic regression and mixed linear models to test for association with AD status and with rate of cognitive decline, respectively. Association with serum levels of 10 cytokines (IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-15, IL-23, INF-γ, and TNF-α) will be conducted using linear regression. We will report our results at the conference. This work will provide insights into the association of rs2228467 and rs6441977 with AD risk, rate of cognitive decline, and serum markers of inflammation. These findings should provide insights into the relationship between these variants and inflammation, in addition to how these factors may influence risk for AD." @default.
- W2897594540 created "2018-10-26" @default.
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- W2897594540 date "2018-07-01" @default.
- W2897594540 modified "2023-10-16" @default.
- W2897594540 title "P2‐130: ASSOCIATION OF CCRL2‐V180M (RS6441977) AND CCBP2‐V41A (RS2228467) WITH AD, COGNITIVE DECLINE, AND SERUM CYTOKINE LEVELS" @default.
- W2897594540 doi "https://doi.org/10.1016/j.jalz.2018.06.816" @default.
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