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• W2897596935 abstract "Abstract Genetic alterations in the transcriptional repressor ETV6 are associated with hematological malignancies. Notably, the t(12;21) translocation leading to an ETV6 -AML1 fusion gene is the most common genetic alteration found in childhood acute lymphoblastic leukemia. Moreover, most of these patients also lack ETV6 expression, suggesting a tumor suppressor function. To gain insights on ETV6 DNA-binding specificity and genome wide transcriptional regulation capacities, we performed chromatin immunoprecipitation experiments coupled to deep sequencing in a t(12;21)-positive pre-B leukemic cell line. This strategy led to the identification of ETV6 -bound regions that were further associated to gene expression. ETV6 binding is mostly cell type-specific as only few regions are shared with other blood cell subtypes. Peaks localization and motif enrichment analyses revealed that this unique binding profile could be associated with the ETV6 -AML1 fusion protein specific to the t(12;21) background. This study underscores the complexity of ETV6 binding and uncovers ETV6 transcriptional network in pre-B leukemia cells bearing the recurrent t(12;21) translocation." @default.
• W2897596935 created "2018-10-26" @default.
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• W2897596935 date "2018-10-19" @default.
• W2897596935 modified "2023-10-12" @default.
• W2897596935 title "Genome wide mapping of ETV6 binding sites in pre-B leukemic cells" @default.
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• W2897596935 doi "https://doi.org/10.1038/s41598-018-33947-1" @default.
• W2897596935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6195514" @default.
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• W2897596935 hasPublicationYear "2018" @default.
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