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• W2897601137 abstract "Mitochondria are increasingly associated with inflammation. Here, we focus on the relationship between inflammation and adenine nucleotide translocator type 1 ( ANT 1), which is localized in the mitochondrial inner membrane. ANT 1 plays an important role in oxidative phosphorylation, and mutations in the ANT 1 gene are responsible for mitochondrial diseases. Ample studies have demonstrated that ANT 1 has a critical role in cardiomyocytes and neurons, but little has been reported on its functions in immune cells. We knocked down ANT 1 expression in macrophages and examined inflammatory cytokine expression after lipopolysaccharide stimulation. ANT 1 knockdown reduces the expression of IL ‐6. JNK , upstream of IL ‐6, is downregulated, but other MAP kinases and the NF ‐κB signaling remain unchanged. These results suggest that ANT 1 modulates IL ‐6 expression through JNK in macrophages." @default.
• W2897601137 created "2018-10-26" @default.
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• W2897601137 date "2018-10-24" @default.
• W2897601137 modified "2023-10-16" @default.
• W2897601137 title "The inner mitochondrial membrane protein<scp>ANT</scp>1 modulates<scp>IL</scp>‐6 expression<i>via</i>the<scp>JNK</scp>pathway in macrophages" @default.
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• W2897601137 doi "https://doi.org/10.1002/1873-3468.13269" @default.
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