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- W2897601156 abstract "Experimental studies in offspring of transgene mice with over expression of insulin-like growth factor I (IGF-I), like in diabetic mice, demonstrated higher brain volumes compared to healthy controls due to an increase of the cortical volume up to 26%. This human study aimed to compare in-vivo MR-based brain volumes of fetuses from diabetic/adipose mothers with fetuses from mothers without underlying metabolic disease. In this prospective we analysed the brain volumes of 52 singleton fetuses from mothers with gestational diabetes (GDM), who underwent fetal MRI between gestational week 27 and 39 on a 1.5 T scanner. Furthermore, the mode of treatment (insulin or diet), and the maternal pregestational body-mass-index was evaluated; a BMI up to 25kg/m2 was considered to be normal, 25.1-30 kg/m2 to be over weighted and ≥30 kg/m2 to be adipose. Differentiated brain volumes were measured with an established software and compared to 108 age-matched fetuses from mothers with no underlying metabolic disease. Fetuses from mothers with GDM showed higher brain volumes compared to fetuses from mothers with no underlying metabolic disease (p < .001). This finding was due to increased cortical volumes (p < .001) compared to age–matched controls. In the subset of fetuses from gestational diabetic and adipose mothers the brain volume correlated well with the maternal BMI (η2 < .120; P < .001). Fetuses of diabetic mothers showed higher brain volumes due to increased cortical volumes compared to age-matched controls. In accordance with the literature we suggest that higher levels of IGF-I (a neuroendocrine regulator of CNS development, maturation and cellular plasticity) might be responsible for this effect. Further studies will have investigate whether increased prenatal IGF-I activity has a long term effect on brain function of the offspring." @default.
- W2897601156 created "2018-10-26" @default.
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- W2897601156 date "2018-10-01" @default.
- W2897601156 modified "2023-10-16" @default.
- W2897601156 title "OC06.07: ‘Supersize me’ gestational diabetes mellitus results in higher fetal brain volumes due to increased cortical volumes: an age-matched comparison" @default.
- W2897601156 doi "https://doi.org/10.1002/uog.19245" @default.
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