Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897601491> ?p ?o ?g. }
- W2897601491 abstract "Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer’s disease. However, the specific role of reactive astrocytes is still debated. This controversy may stem from the fact that most strategies used to modulate astrocyte reactivity and explore its contribution to disease outcomes have only limited specificity. Moreover, reactive astrocytes are now emerging as heterogeneous cells and all types of astrocyte reactivity may not be controlled efficiently by such strategies. Here, we used cell type-specific approaches in vivo and identified the JAK2-STAT3 pathway, as necessary and sufficient for the induction and maintenance of astrocyte reactivity. Modulation of this cascade by viral gene transfer in mouse astrocytes efficiently controlled several morphological and molecular features of reactivity. Inhibition of this pathway in mouse models of Alzheimer’s disease improved three key pathological hallmarks by reducing amyloid deposition, improving spatial learning and restoring synaptic deficits. In conclusion, the JAK2-STAT3 cascade operates as a master regulator of astrocyte reactivity in vivo. Its inhibition offers new therapeutic opportunities for Alzheimer’s disease." @default.
- W2897601491 created "2018-10-26" @default.
- W2897601491 creator A5003701057 @default.
- W2897601491 creator A5003805886 @default.
- W2897601491 creator A5004430637 @default.
- W2897601491 creator A5004590713 @default.
- W2897601491 creator A5009504265 @default.
- W2897601491 creator A5012649564 @default.
- W2897601491 creator A5013775498 @default.
- W2897601491 creator A5013839554 @default.
- W2897601491 creator A5013947713 @default.
- W2897601491 creator A5019346214 @default.
- W2897601491 creator A5023363225 @default.
- W2897601491 creator A5024251772 @default.
- W2897601491 creator A5024687365 @default.
- W2897601491 creator A5031149700 @default.
- W2897601491 creator A5033459115 @default.
- W2897601491 creator A5039267078 @default.
- W2897601491 creator A5040501446 @default.
- W2897601491 creator A5041762737 @default.
- W2897601491 creator A5043094295 @default.
- W2897601491 creator A5045973045 @default.
- W2897601491 creator A5048386672 @default.
- W2897601491 creator A5049067226 @default.
- W2897601491 creator A5049107218 @default.
- W2897601491 creator A5050514707 @default.
- W2897601491 creator A5051377002 @default.
- W2897601491 creator A5055643860 @default.
- W2897601491 creator A5065418218 @default.
- W2897601491 creator A5075364131 @default.
- W2897601491 creator A5076819006 @default.
- W2897601491 creator A5078339125 @default.
- W2897601491 creator A5078877246 @default.
- W2897601491 creator A5082397800 @default.
- W2897601491 date "2018-10-16" @default.
- W2897601491 modified "2023-10-09" @default.
- W2897601491 title "Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease" @default.
- W2897601491 cites W1569924411 @default.
- W2897601491 cites W1642543027 @default.
- W2897601491 cites W1876891236 @default.
- W2897601491 cites W1925771428 @default.
- W2897601491 cites W1951581594 @default.
- W2897601491 cites W1955394435 @default.
- W2897601491 cites W1966327575 @default.
- W2897601491 cites W1967464880 @default.
- W2897601491 cites W1969492297 @default.
- W2897601491 cites W1972685619 @default.
- W2897601491 cites W1977958644 @default.
- W2897601491 cites W1983061009 @default.
- W2897601491 cites W1984988736 @default.
- W2897601491 cites W1988664434 @default.
- W2897601491 cites W1993554906 @default.
- W2897601491 cites W1993573917 @default.
- W2897601491 cites W1994630549 @default.
- W2897601491 cites W1998905522 @default.
- W2897601491 cites W2000225222 @default.
- W2897601491 cites W2006140418 @default.
- W2897601491 cites W2007809048 @default.
- W2897601491 cites W2010476270 @default.
- W2897601491 cites W2010683624 @default.
- W2897601491 cites W2012601853 @default.
- W2897601491 cites W2017169966 @default.
- W2897601491 cites W2017816448 @default.
- W2897601491 cites W2019663192 @default.
- W2897601491 cites W2019682082 @default.
- W2897601491 cites W2033215199 @default.
- W2897601491 cites W2037200077 @default.
- W2897601491 cites W2038274440 @default.
- W2897601491 cites W2038594716 @default.
- W2897601491 cites W2039067152 @default.
- W2897601491 cites W2042681276 @default.
- W2897601491 cites W2043162503 @default.
- W2897601491 cites W2047585900 @default.
- W2897601491 cites W2050523782 @default.
- W2897601491 cites W2052870901 @default.
- W2897601491 cites W2082429191 @default.
- W2897601491 cites W2084566588 @default.
- W2897601491 cites W2087243986 @default.
- W2897601491 cites W2101363175 @default.
- W2897601491 cites W2103440561 @default.
- W2897601491 cites W2106729121 @default.
- W2897601491 cites W2109805561 @default.
- W2897601491 cites W2111353279 @default.
- W2897601491 cites W2116224426 @default.
- W2897601491 cites W2121860798 @default.
- W2897601491 cites W2122037893 @default.
- W2897601491 cites W2124940469 @default.
- W2897601491 cites W2135968732 @default.
- W2897601491 cites W2139663796 @default.
- W2897601491 cites W2142943752 @default.
- W2897601491 cites W2157585985 @default.
- W2897601491 cites W2158217645 @default.
- W2897601491 cites W2164490896 @default.
- W2897601491 cites W2167183660 @default.
- W2897601491 cites W2168334242 @default.
- W2897601491 cites W2169456326 @default.
- W2897601491 cites W2169708427 @default.
- W2897601491 cites W2171311951 @default.
- W2897601491 cites W2172477756 @default.
- W2897601491 cites W2179438025 @default.