FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897612050> ?p ?o ?g. }

• W2897612050 endingPage "1804956" @default.
• W2897612050 startingPage "1804956" @default.
• W2897612050 abstract "Fluorescence imaging in the second near-infrared (NIR-II) window holds impressive advantages of enhanced penetration depth and improved signal-to-noise ratio. Bright NIR-II fluorophores with renal excretion ability and low tissue accumulation are favorable for in vivo molecular imaging applications as they can render the target-mediated molecular imaging process easily distinguishable. Here, a probe (anti-PD-L1-BGP6) comprising a fluorophore (IR-BGP6) covalently bonded to the programmed cell death ligand-1 monoclonal antibody (PD-L1 mAb) for molecular imaging of immune checkpoint PD-L1 (a targeting site upregulated in various tumors for cancer imaging) in the NIR-II window is reported. Through molecular optimization, the bright NIR-II fluorophore IR-BGP6 with fast renal excretion (≈91% excretion in general through urine within the first 10 h postinjection) is developed. The conjugate anti-PD-L1-BGP6 succeeds in profiling PD-L1 expression and realizes efficient noninvasive molecular imaging in vivo, achieving a tumor to normal tissue (T/NT) signal ratio as high as ≈9.5. Compared with the NIR-II fluorophore with high nonspecific tissue accumulation, IR-BGP6 derived PD-L1 imaging significantly enhances the molecular imaging performance, serving as a strong tool for potentially studying underlying mechanism of immunotherapy. The work provides rationales to design renal-excreted NIR-II fluorophores and illustrate their advantages for in vivo molecular imaging." @default.
• W2897612050 created "2018-10-26" @default.
• W2897612050 creator A5010781195 @default.
• W2897612050 creator A5011508317 @default.
• W2897612050 creator A5016140115 @default.
• W2897612050 creator A5017109982 @default.
• W2897612050 creator A5024032010 @default.
• W2897612050 creator A5029525185 @default.
• W2897612050 creator A5030412826 @default.
• W2897612050 creator A5046315806 @default.
• W2897612050 creator A5052823796 @default.
• W2897612050 creator A5054204107 @default.
• W2897612050 creator A5062260595 @default.
• W2897612050 creator A5064967221 @default.
• W2897612050 creator A5075171995 @default.
• W2897612050 creator A5077420983 @default.
• W2897612050 creator A5081480904 @default.
• W2897612050 creator A5091082145 @default.
• W2897612050 date "2018-10-22" @default.
• W2897612050 modified "2023-10-17" @default.
• W2897612050 title "Developing a Bright NIR‐II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD‐L1" @default.
• W2897612050 cites W1965097716 @default.
• W2897612050 cites W1984705626 @default.
• W2897612050 cites W2001140567 @default.
• W2897612050 cites W2042699075 @default.
• W2897612050 cites W2043680485 @default.
• W2897612050 cites W2045936365 @default.
• W2897612050 cites W2066671159 @default.
• W2897612050 cites W2073948019 @default.
• W2897612050 cites W2079625753 @default.
• W2897612050 cites W2090360437 @default.
• W2897612050 cites W2115525058 @default.
• W2897612050 cites W2118396147 @default.
• W2897612050 cites W2163040806 @default.
• W2897612050 cites W2261575366 @default.
• W2897612050 cites W2290610287 @default.
• W2897612050 cites W2294356527 @default.
• W2897612050 cites W2319850974 @default.
• W2897612050 cites W2416606193 @default.
• W2897612050 cites W2551624291 @default.
• W2897612050 cites W2560367415 @default.
• W2897612050 cites W2561520100 @default.
• W2897612050 cites W2569658671 @default.
• W2897612050 cites W2579122533 @default.
• W2897612050 cites W2582561014 @default.
• W2897612050 cites W2589348410 @default.
• W2897612050 cites W2605166062 @default.
• W2897612050 cites W2606668319 @default.
• W2897612050 cites W2621587943 @default.
• W2897612050 cites W2623412210 @default.
• W2897612050 cites W2747657278 @default.
• W2897612050 cites W2760538791 @default.
• W2897612050 cites W2767203585 @default.
• W2897612050 cites W2767777133 @default.
• W2897612050 cites W2767824485 @default.
• W2897612050 cites W2782748022 @default.
• W2897612050 cites W2786965675 @default.
• W2897612050 cites W2794186026 @default.
• W2897612050 cites W2799662486 @default.
• W2897612050 cites W2799708965 @default.
• W2897612050 cites W4251581159 @default.
• W2897612050 doi "https://doi.org/10.1002/adfm.201804956" @default.
• W2897612050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6907024" @default.
• W2897612050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31832053" @default.
• W2897612050 hasPublicationYear "2018" @default.
• W2897612050 type Work @default.
• W2897612050 sameAs 2897612050 @default.
• W2897612050 citedByCount "78" @default.
• W2897612050 countsByYear W28976120502019 @default.
• W2897612050 countsByYear W28976120502020 @default.
• W2897612050 countsByYear W28976120502021 @default.
• W2897612050 countsByYear W28976120502022 @default.
• W2897612050 countsByYear W28976120502023 @default.
• W2897612050 crossrefType "journal-article" @default.
• W2897612050 hasAuthorship W2897612050A5010781195 @default.
• W2897612050 hasAuthorship W2897612050A5011508317 @default.
• W2897612050 hasAuthorship W2897612050A5016140115 @default.
• W2897612050 hasAuthorship W2897612050A5017109982 @default.
• W2897612050 hasAuthorship W2897612050A5024032010 @default.
• W2897612050 hasAuthorship W2897612050A5029525185 @default.
• W2897612050 hasAuthorship W2897612050A5030412826 @default.
• W2897612050 hasAuthorship W2897612050A5046315806 @default.
• W2897612050 hasAuthorship W2897612050A5052823796 @default.
• W2897612050 hasAuthorship W2897612050A5054204107 @default.
• W2897612050 hasAuthorship W2897612050A5062260595 @default.
• W2897612050 hasAuthorship W2897612050A5064967221 @default.
• W2897612050 hasAuthorship W2897612050A5075171995 @default.
• W2897612050 hasAuthorship W2897612050A5077420983 @default.
• W2897612050 hasAuthorship W2897612050A5081480904 @default.
• W2897612050 hasAuthorship W2897612050A5091082145 @default.
• W2897612050 hasBestOaLocation W28976120502 @default.
• W2897612050 hasConcept C120665830 @default.
• W2897612050 hasConcept C121332964 @default.
• W2897612050 hasConcept C12554922 @default.
• W2897612050 hasConcept C134306372 @default.
• W2897612050 hasConcept C136339569 @default.
• W2897612050 hasConcept C145169222 @default.
• W2897612050 hasConcept C150903083 @default.

• next