FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897612425> ?p ?o ?g. }

• W2897612425 endingPage "e0204799" @default.
• W2897612425 startingPage "e0204799" @default.
• W2897612425 abstract "Background & objectives Vaccine safety signals require investigation, which may be done rapidly at the population level using ecological studies, before embarking on hypothesis-testing studies. Incidence rates were used to assess a signal of narcolepsy following AS03-adjuvanted monovalent pandemic H1N1 (pH1N1) influenza vaccination among children and adolescents in Sweden and Finland in 2010. We explored the utility of ecological data to assess incidence of narcolepsy following exposure to pandemic H1N1 virus or vaccination in 10 sites that used different vaccines, adjuvants, and had varying vaccine coverage. Methods We calculated incidence rates of diagnosed narcolepsy for periods defined by influenza virus circulation and vaccination campaign dates, and used Poisson regression to estimate incidence rate ratios (IRRs) comparing the periods during which wild-type virus circulated and after the start of vaccination campaigns vs. the period prior to pH1N1 virus circulation. We used electronic health care data from Sweden, Denmark, the United Kingdom, Canada (3 provinces), Taiwan, Netherlands, and Spain (2 regions) from 2003 to 2013. We investigated interactions between age group and adjuvant in European sites and conducted a simulation study to investigate how vaccine coverage, age, and the interval from onset to diagnosis may impact the ability to detect safety signals. Results Incidence rates of narcolepsy varied by age, continent, and period. Only in Taiwan and Sweden were significant time-period-by-age-group interactions observed. Associations were found for children in Taiwan (following pH1N1 virus circulation) and Sweden (following vaccination). Simulations showed that the individual-level relative risk of narcolepsy was underestimated using ecological methods comparing post- vs. pre-vaccination periods; this effect was attenuated with higher vaccine coverage and a shorter interval from disease onset to diagnosis. Conclusions Ecological methods can be useful for vaccine safety assessment but the results are influenced by diagnostic delay and vaccine coverage. Because ecological methods assess risk at the population level, these methods should be treated as signal-generating methods and drawing conclusions regarding individual-level risk should be avoided." @default.
• W2897612425 created "2018-10-26" @default.
• W2897612425 creator A5001487803 @default.
• W2897612425 creator A5004625182 @default.
• W2897612425 creator A5011711127 @default.
• W2897612425 creator A5032941229 @default.
• W2897612425 creator A5034354208 @default.
• W2897612425 creator A5038878885 @default.
• W2897612425 creator A5039535069 @default.
• W2897612425 creator A5045745471 @default.
• W2897612425 creator A5048518734 @default.
• W2897612425 creator A5059165461 @default.
• W2897612425 creator A5063302222 @default.
• W2897612425 creator A5068452972 @default.
• W2897612425 creator A5078064190 @default.
• W2897612425 creator A5078254234 @default.
• W2897612425 creator A5078783858 @default.
• W2897612425 creator A5080252318 @default.
• W2897612425 creator A5081728498 @default.
• W2897612425 creator A5082236476 @default.
• W2897612425 creator A5086460777 @default.
• W2897612425 date "2018-10-17" @default.
• W2897612425 modified "2023-10-18" @default.
• W2897612425 title "Incidence rates of narcolepsy diagnoses in Taiwan, Canada, and Europe: The use of statistical simulation to evaluate methods for the rapid assessment of potential safety issues on a population level in the SOMNIA study" @default.
• W2897612425 cites W1519320417 @default.
• W2897612425 cites W1952543825 @default.
• W2897612425 cites W1966147876 @default.
• W2897612425 cites W1975469223 @default.
• W2897612425 cites W1994656802 @default.
• W2897612425 cites W2007032418 @default.
• W2897612425 cites W2014556895 @default.
• W2897612425 cites W2016590606 @default.
• W2897612425 cites W2031302069 @default.
• W2897612425 cites W2064985199 @default.
• W2897612425 cites W2070144977 @default.
• W2897612425 cites W2079950469 @default.
• W2897612425 cites W2082374263 @default.
• W2897612425 cites W2084797556 @default.
• W2897612425 cites W2115739016 @default.
• W2897612425 cites W2120653344 @default.
• W2897612425 cites W2124125947 @default.
• W2897612425 cites W2127306596 @default.
• W2897612425 cites W2130741672 @default.
• W2897612425 cites W2136183510 @default.
• W2897612425 cites W2138558919 @default.
• W2897612425 cites W2148384395 @default.
• W2897612425 cites W2152258000 @default.
• W2897612425 cites W2155669879 @default.
• W2897612425 cites W2274944932 @default.
• W2897612425 cites W2284175055 @default.
• W2897612425 cites W2296505176 @default.
• W2897612425 cites W2346820406 @default.
• W2897612425 cites W2587026604 @default.
• W2897612425 cites W413426421 @default.
• W2897612425 cites W4238302500 @default.
• W2897612425 doi "https://doi.org/10.1371/journal.pone.0204799" @default.
• W2897612425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192586" @default.
• W2897612425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332477" @default.
• W2897612425 hasPublicationYear "2018" @default.
• W2897612425 type Work @default.
• W2897612425 sameAs 2897612425 @default.
• W2897612425 citedByCount "16" @default.
• W2897612425 countsByYear W28976124252018 @default.
• W2897612425 countsByYear W28976124252019 @default.
• W2897612425 countsByYear W28976124252020 @default.
• W2897612425 countsByYear W28976124252021 @default.
• W2897612425 countsByYear W28976124252022 @default.
• W2897612425 countsByYear W28976124252023 @default.
• W2897612425 crossrefType "journal-article" @default.
• W2897612425 hasAuthorship W2897612425A5001487803 @default.
• W2897612425 hasAuthorship W2897612425A5004625182 @default.
• W2897612425 hasAuthorship W2897612425A5011711127 @default.
• W2897612425 hasAuthorship W2897612425A5032941229 @default.
• W2897612425 hasAuthorship W2897612425A5034354208 @default.
• W2897612425 hasAuthorship W2897612425A5038878885 @default.
• W2897612425 hasAuthorship W2897612425A5039535069 @default.
• W2897612425 hasAuthorship W2897612425A5045745471 @default.
• W2897612425 hasAuthorship W2897612425A5048518734 @default.
• W2897612425 hasAuthorship W2897612425A5059165461 @default.
• W2897612425 hasAuthorship W2897612425A5063302222 @default.
• W2897612425 hasAuthorship W2897612425A5068452972 @default.
• W2897612425 hasAuthorship W2897612425A5078064190 @default.
• W2897612425 hasAuthorship W2897612425A5078254234 @default.
• W2897612425 hasAuthorship W2897612425A5078783858 @default.
• W2897612425 hasAuthorship W2897612425A5080252318 @default.
• W2897612425 hasAuthorship W2897612425A5081728498 @default.
• W2897612425 hasAuthorship W2897612425A5082236476 @default.
• W2897612425 hasAuthorship W2897612425A5086460777 @default.
• W2897612425 hasBestOaLocation W28976124251 @default.
• W2897612425 hasConcept C118552586 @default.
• W2897612425 hasConcept C120665830 @default.
• W2897612425 hasConcept C121332964 @default.
• W2897612425 hasConcept C126322002 @default.
• W2897612425 hasConcept C144024400 @default.
• W2897612425 hasConcept C149923435 @default.
• W2897612425 hasConcept C16568411 @default.
• W2897612425 hasConcept C167704817 @default.
• W2897612425 hasConcept C187212893 @default.

• next