FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897612576> ?p ?o ?g. }

• W2897612576 abstract "Brain volume loss is a marker of dementia-associated neurodegeneration. We investigated the relative contributions of aging and seven modifiable dementia risk factors (MDRF, hypertension, diabetes, obesity, frequent alcohol consumption, smoking, inadequate sleep, and lack of college degree education) for explaining differences in brain volume. Data from 8312 UK Biobank participants (62.4±7.4yrs, 47.1% men) without brain neurological or psychiatric diseases who underwent 3T structural brain MRI (Access Agreement 18545) were used to examine effect sizes and anatomical distributions of brain grey and white matter differences associated with MDRF relative to those found with aging. A multiple regression model estimated independent contributions of age and MDRF (corrected p<0.05). Brain volumes were 0.41% lower mean volume/year of age, with greater age-related differences in grey matter (0.53%) than in white matter (0.24%). MDRF accounted individually for variable additional, independent differences in brain volume (all values expressed as % lower total brain volume (TBV)): diabetes (2.1%) > frequent alcohol consumption (0.68%) ∼ obesity (0.51%) > hypertension (0.31%). An association between smoking and total grey matter volume was found, but subjects’ reports of inadequate sleep or lack of college degree education were not significantly associated with brain volume measures. Voxel-wise parametric variations tested using Statistical Parametric Mapping (SPM 12) showed 74% of TBV varied negatively with age. This included 84% of the total grey and 59% of the total white matter volume (p<0.025, family-wise error [FEW] corrected). Focal brain volumes negatively associated with the seven MDRF (all values expressed as % TBV) were within the brain volume influenced by age: diabetes (23.1%) > obesity (6.2%) ∼ hypertension (5.6%) > frequent alcohol consumption (2.3%) > lack of college degree education (0.8%) > smoking and inadequate sleep (<0.01%) (p<0.025, FWE corrected). Our results highlight highly significant associations between lower brain volumes and MDRF. The greatest effect size was found with diabetes, followed by hypertension, obesity, and frequent alcohol consumption. This suggests the potential relative impacts on late life cognitive impairment from public health measures targeting these risks. The anatomically overlapping independent aging and MDRF effects suggest that they influence common brain regions additively." @default.
• W2897612576 created "2018-10-26" @default.
• W2897612576 creator A5015222308 @default.
• W2897612576 creator A5070529061 @default.
• W2897612576 date "2018-07-01" @default.
• W2897612576 modified "2023-10-16" @default.
• W2897612576 title "P1‐032: RELATIVE IMPACTS OF AGING AND MODIFIABLE RISK FACTORS FOR DEMENTIA ON BRAIN VOLUMES IN THE UK BIOBANK COHORT" @default.
• W2897612576 doi "https://doi.org/10.1016/j.jalz.2018.06.033" @default.
• W2897612576 hasPublicationYear "2018" @default.
• W2897612576 type Work @default.
• W2897612576 sameAs 2897612576 @default.
• W2897612576 citedByCount "1" @default.
• W2897612576 countsByYear W28976125762022 @default.
• W2897612576 crossrefType "journal-article" @default.
• W2897612576 hasAuthorship W2897612576A5015222308 @default.
• W2897612576 hasAuthorship W2897612576A5070529061 @default.
• W2897612576 hasConcept C126322002 @default.
• W2897612576 hasConcept C126838900 @default.
• W2897612576 hasConcept C134018914 @default.
• W2897612576 hasConcept C143409427 @default.
• W2897612576 hasConcept C164705383 @default.
• W2897612576 hasConcept C2778013878 @default.
• W2897612576 hasConcept C2779134260 @default.
• W2897612576 hasConcept C2779483572 @default.
• W2897612576 hasConcept C2781192897 @default.
• W2897612576 hasConcept C39313694 @default.
• W2897612576 hasConcept C555293320 @default.
• W2897612576 hasConcept C65835030 @default.
• W2897612576 hasConcept C71924100 @default.
• W2897612576 hasConcept C72563966 @default.
• W2897612576 hasConceptScore W2897612576C126322002 @default.
• W2897612576 hasConceptScore W2897612576C126838900 @default.
• W2897612576 hasConceptScore W2897612576C134018914 @default.
• W2897612576 hasConceptScore W2897612576C143409427 @default.
• W2897612576 hasConceptScore W2897612576C164705383 @default.
• W2897612576 hasConceptScore W2897612576C2778013878 @default.
• W2897612576 hasConceptScore W2897612576C2779134260 @default.
• W2897612576 hasConceptScore W2897612576C2779483572 @default.
• W2897612576 hasConceptScore W2897612576C2781192897 @default.
• W2897612576 hasConceptScore W2897612576C39313694 @default.
• W2897612576 hasConceptScore W2897612576C555293320 @default.
• W2897612576 hasConceptScore W2897612576C65835030 @default.
• W2897612576 hasConceptScore W2897612576C71924100 @default.
• W2897612576 hasConceptScore W2897612576C72563966 @default.
• W2897612576 hasIssue "7S_Part_5" @default.
• W2897612576 hasLocation W28976125761 @default.
• W2897612576 hasOpenAccess W2897612576 @default.
• W2897612576 hasPrimaryLocation W28976125761 @default.
• W2897612576 hasRelatedWork W1913052892 @default.
• W2897612576 hasRelatedWork W1985905477 @default.
• W2897612576 hasRelatedWork W2000009382 @default.
• W2897612576 hasRelatedWork W2017977110 @default.
• W2897612576 hasRelatedWork W2071412356 @default.
• W2897612576 hasRelatedWork W2131014005 @default.
• W2897612576 hasRelatedWork W2591896852 @default.
• W2897612576 hasRelatedWork W2953860399 @default.
• W2897612576 hasRelatedWork W3032544972 @default.
• W2897612576 hasRelatedWork W4283278429 @default.
• W2897612576 hasVolume "14" @default.
• W2897612576 isParatext "false" @default.
• W2897612576 isRetracted "false" @default.
• W2897612576 magId "2897612576" @default.
• W2897612576 workType "article" @default.