Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897614678> ?p ?o ?g. }
- W2897614678 abstract "Current treatment modalities for cancer have been successful in achieving improved survivorship; however, they come with a number of long-term adverse effects. Accidental falls are a common and clinically significant adverse event in people living with and beyond cancer and rates are higher than in the rest of the population.To assess the effects of prescribed or provided exercise for reducing accidental falls, and falls risk factors of strength, flexibility and balance, in people living with and beyond cancer.We searched the following electronic databases from inception to 10 July 2018, with no restrictions: CENTRAL, MEDLINE, Embase, and seven other databases. We searched clinicaltrials.gov and the World Health Organization International Clinical Trials Registry Platform (ICTRP) for ongoing trials, and reference lists of reviews and retrieved articles for additional studies.We included all randomised controlled trials investigating exercise interventions versus no treatment, usual care or non-exercise interventions on falls incidence or falls risk factors in adults living with and beyond cancer (18 years of age or older at diagnosis). We excluded cross-over studies and studies in acute or inpatient hospice care.At least two review authors independently completed data extraction for included papers. We used Covidence software to manage screening, data collection and extraction. We assessed evidence using GRADE and presented results in a 'Summary of findings' table.Eleven studies (835 participants) compared exercise to usual care. No studies compared exercise with no treatment or non-exercise interventions. The quality of the evidence was very low for the primary outcome rates of falls, and very low to low for the secondary outcomes. We downgraded the evidence due to study limitations (risk of bias), and issues of imprecision due to small sample sizes, inconsistency and indirectness. All studies were at high risk of bias for blinding of participants and personnel due to inability to blind participants to an exercise intervention. Risk of bias was generally low or unclear for other categories.There was generally little information on the important outcomes comparing exercise to usual care.Rates of falls and number of fallers: one study (223 participants) measured accidental falls, but reported neither the rate of falls or the number of fallers; there was no difference in the number of falls between exercise and usual care (very low-quality evidence).Strength: 10 studies (813 participants) reported on strength outcomes. Two analyses favoured exercise over usual care: quadriceps strength (2 studies, 72 participants; mean difference (MD) 8.99 kg, 95% confidence interval (CI) 1.29 to 16.70; low-quality evidence), and leg press (4 studies, 388 participants; MD 21.1 kg, 95% CI 8.47 to 33.74; low-quality evidence). In one analysis of the Sit-to-Stand Test, there was no difference between exercise and usual care (4 studies, 214 participants; standardised mean difference (SMD) -0.45, 95% CI -1.05 to 0.14; very low-quality evidence).Flexibility: one study (21 participants) reported on flexibility for Sit-and-Reach Distance (MD 2.05 cm, 95% CI 0.59 to 3.51; very low-quality evidence).Balance: five studies (350 participants) measured three different balance outcomes. Two analyses favoured exercise over usual care: postural balance (4 studies, 127 participants; standardised mean difference (SMD) 0.44, 95% CI 0.08 to 0.79; very low-quality evidence), and Backward Walk Test (2 studies, 280 participants; SMD -0.24, 95% CI -0.48 to -0.01; low-quality evidence). There was no difference between exercise and usual care for the Timed Up-and-Go Test (1 study, 15 participants; MD -0.35 seconds, 95% CI -1.47 to 0.77; low-quality evidence).Number of people sustaining a fall-related fracture: the quality of the evidence for exercise reducing fall-related fractures was very low.Adverse events: a single study (223 participants) noted some temporary muscle soreness on initiation of exercise or when there was an increase in the weight lifted. As no occurrence data were reported, we could not assess this variable further. No studies reported musculoskeletal injury. Analysis indicated that there was very low-quality evidence that exercise did not increase fatigue.There is a paucity of evidence for exercise training to reduce fall rates in people living with and beyond cancer. Exercise training may improve strength, flexibility and balance for people in this population, but the evidence is very low quality." @default.
- W2897614678 created "2018-10-26" @default.
- W2897614678 creator A5020656488 @default.
- W2897614678 creator A5023503244 @default.
- W2897614678 creator A5072334766 @default.
- W2897614678 creator A5073920039 @default.
- W2897614678 creator A5074442370 @default.
- W2897614678 creator A5080369586 @default.
- W2897614678 date "2018-10-15" @default.
- W2897614678 modified "2023-10-18" @default.
- W2897614678 title "Exercise for reducing falls in people living with and beyond cancer" @default.
- W2897614678 cites W1491259965 @default.
- W2897614678 cites W1598330538 @default.
- W2897614678 cites W1757407923 @default.
- W2897614678 cites W1864731096 @default.
- W2897614678 cites W1891668437 @default.
- W2897614678 cites W1942885778 @default.
- W2897614678 cites W1969356358 @default.
- W2897614678 cites W1969536713 @default.
- W2897614678 cites W1969574813 @default.
- W2897614678 cites W1970516314 @default.
- W2897614678 cites W1974704788 @default.
- W2897614678 cites W1981767305 @default.
- W2897614678 cites W1992150054 @default.
- W2897614678 cites W1995170940 @default.
- W2897614678 cites W1997732940 @default.
- W2897614678 cites W2006479712 @default.
- W2897614678 cites W2009938720 @default.
- W2897614678 cites W2012203078 @default.
- W2897614678 cites W2016245229 @default.
- W2897614678 cites W2016972400 @default.
- W2897614678 cites W2020283399 @default.
- W2897614678 cites W2024824220 @default.
- W2897614678 cites W2029403247 @default.
- W2897614678 cites W2030387756 @default.
- W2897614678 cites W2031475323 @default.
- W2897614678 cites W2033380798 @default.
- W2897614678 cites W2039471900 @default.
- W2897614678 cites W2040494114 @default.
- W2897614678 cites W2045117838 @default.
- W2897614678 cites W2045462605 @default.
- W2897614678 cites W204731580 @default.
- W2897614678 cites W2054332802 @default.
- W2897614678 cites W2057681998 @default.
- W2897614678 cites W2058032927 @default.
- W2897614678 cites W2059727515 @default.
- W2897614678 cites W2059998155 @default.
- W2897614678 cites W2060762518 @default.
- W2897614678 cites W2064698266 @default.
- W2897614678 cites W2074802649 @default.
- W2897614678 cites W2086359280 @default.
- W2897614678 cites W2089775493 @default.
- W2897614678 cites W2090003526 @default.
- W2897614678 cites W2090132603 @default.
- W2897614678 cites W2090348823 @default.
- W2897614678 cites W2097003384 @default.
- W2897614678 cites W2097443151 @default.
- W2897614678 cites W2100090684 @default.
- W2897614678 cites W2100689842 @default.
- W2897614678 cites W2101076802 @default.
- W2897614678 cites W2101077754 @default.
- W2897614678 cites W2103252230 @default.
- W2897614678 cites W2105600708 @default.
- W2897614678 cites W2107519665 @default.
- W2897614678 cites W2111233815 @default.
- W2897614678 cites W2112672701 @default.
- W2897614678 cites W2113051457 @default.
- W2897614678 cites W2114808153 @default.
- W2897614678 cites W2117291264 @default.
- W2897614678 cites W2120519520 @default.
- W2897614678 cites W2123650042 @default.
- W2897614678 cites W2129820993 @default.
- W2897614678 cites W2132087344 @default.
- W2897614678 cites W2148441650 @default.
- W2897614678 cites W2151580437 @default.
- W2897614678 cites W2152725683 @default.
- W2897614678 cites W2156098321 @default.
- W2897614678 cites W2157375067 @default.
- W2897614678 cites W2167308615 @default.
- W2897614678 cites W2172043436 @default.
- W2897614678 cites W2179852395 @default.
- W2897614678 cites W2181211854 @default.
- W2897614678 cites W2200049143 @default.
- W2897614678 cites W2211688404 @default.
- W2897614678 cites W2227813149 @default.
- W2897614678 cites W2264206415 @default.
- W2897614678 cites W2274482469 @default.
- W2897614678 cites W2287268147 @default.
- W2897614678 cites W2288334788 @default.
- W2897614678 cites W2299978209 @default.
- W2897614678 cites W2346081364 @default.
- W2897614678 cites W2416778927 @default.
- W2897614678 cites W2433515948 @default.
- W2897614678 cites W246286872 @default.
- W2897614678 cites W2493427837 @default.
- W2897614678 cites W2527685915 @default.
- W2897614678 cites W2528068579 @default.
- W2897614678 cites W2571885005 @default.
- W2897614678 cites W2740876330 @default.
- W2897614678 cites W2810250749 @default.