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- W2897617622 abstract "Genetic characterization of osteosarcoma has evolved during the last decade, thanks to the integrated application of conventional and new candidate-driven and genome-wide technologies. Areas covered: This review provides an overview of the state of art in genetic testing applied to osteosarcoma, with particular regard to novel candidate genetic biomarkers that can be analyzed in tumor tissue and blood samples, which might be used to predict toxicity and prognosis, detect disease relapse, and improve patients' selection criteria for tailoring treatment. Expert commentary: Genetic testing based on modern technologies is expected to indicate new osteosarcoma-related prognostic markers and driver genes, which may highlight novel therapeutic targets and patients stratification biomarkers. The definition of tailored or targeted treatment approaches may improve outcome of patients with localized tumors and, even more, of those with metastatic disease, for whom progress in cure probability is highly warranted." @default.
- W2897617622 created "2018-10-26" @default.
- W2897617622 creator A5035392874 @default.
- W2897617622 creator A5056195848 @default.
- W2897617622 creator A5062558482 @default.
- W2897617622 creator A5075329373 @default.
- W2897617622 creator A5076117259 @default.
- W2897617622 creator A5083948167 @default.
- W2897617622 creator A5088555951 @default.
- W2897617622 date "2018-10-19" @default.
- W2897617622 modified "2023-09-29" @default.
- W2897617622 title "Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?" @default.
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